124309-74-6 Usage
Uses
Used in Pharmaceutical Industry:
4-Chloroquinazolin-2-amine is used as an intermediate in the synthesis of various pharmaceuticals for its potential anti-cancer properties. It exhibits antiproliferative and proapoptotic activities in cancer cells, making it a promising candidate for the development of new anti-cancer drugs.
Used in Agrochemical Industry:
4-Chloroquinazolin-2-amine is used as an intermediate in the synthesis of agrochemicals, contributing to the development of effective and targeted pest control solutions.
Used in Fine Chemicals Industry:
As a quinazoline derivative, 4-chloroquinazolin-2-amine is used in the synthesis of various fine chemicals, expanding the range of applications in different industries.
Used in Material Science:
4-Chloroquinazolin-2-amine is utilized in the development of new materials, taking advantage of its unique chemical properties to create innovative and functional materials.
Used in Organic Synthesis:
As a building block for the synthesis of various functionalized quinazolines, 4-chloroquinazolin-2-amine plays a crucial role in organic synthesis, enabling the creation of a wide range of chemical compounds with diverse applications.
Check Digit Verification of cas no
The CAS Registry Mumber 124309-74-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,4,3,0 and 9 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 124309-74:
(8*1)+(7*2)+(6*4)+(5*3)+(4*0)+(3*9)+(2*7)+(1*4)=106
106 % 10 = 6
So 124309-74-6 is a valid CAS Registry Number.
124309-74-6Relevant academic research and scientific papers
Reversible Inhibitors of the Gastric (H+/K+)-ATPase. 5. Substituted 2,4-Diaminoquinazolines and Thienopyrimidines
Ife, Robert J.,Brown, Thomas H.,Blurton, Peter,Keeling, David J.,Leach, Colin A.,et al.
, p. 2763 - 2773 (2007/10/03)
Quinazolines bearing a secondary 4-(arylamino) substituent demonstrate an SAR for inhibition of the gastric (H+/K+)-ATPase different from the previously described 3-acylquinolines, suggesting that, although these compounds are also K+-competitive, they probably bind to the enzyme in a different orientation.Compounds bearing a tertiary 4-(arylamino)substituent, however, in particular 4-(N-methylarylamino), appear to possess an SAR quite similar to the 3-acylquinolines.We show that this arises from the effect of the N-methylation, which is to orientate the 4-(arylamino) substituent syn to C5, analogous to the 3-acylquinolines.Compounds possessing both a 4-(N-methylarylamino) substituent and a 2-(arylamino) substituent proved to be very potent, K+-competitive inhibitors of K+-stimulated ATPase activity with Ki values down to 12 nM.Some compounds also proved to be effective inhibitors of stimulated acid secretion in both the rat and dog when dosed intravenously.However, although a number of these demonstrated activity after oral administration in the dog, the level and variability precluded further evaluation.
Quinazoline derivatives
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, (2008/06/13)
Compounds of structure (I): in which, , R1 to R4 are the same or different and are each hydrogen, C1 4alkyl, C1 4alkoxy, phenyl, C1 4alkylthio, C1 4alkanoyl
