124315-52-2

Upstream product

• 105-56-6 ethyl 2-cyanoacetate 
• 28317-57-9 phenylazo acetylacetonitrile 
• 124315-58-8 1,6-dihydro-6-imino-4-methyl-1-phenylpyridazine-3,5-dicarbonitrile 
• 176752-00-4 (2E)-3-oxo-2-(2-phenylhydrazinylidene)butanenitrile 
• 297766-64-4 1,3-Diphenyltriazen 

Downstream Products

• 174968-30-0 4-<2-(N,N-dimethylamino)ethenyl>-6-oxo-1-phenyl-1,6-dihydropyridazine-3,5-dicarbonitrile 
• 128763-71-3 8-Amino-7-cyano-2,3-dihydro-3-oxo-6-phenyl-2-p-tolylcinnolin-4-carboxylic acid 
• 174968-40-2 3,8-Dioxo-2-phenyl-2,3,7,8-tetrahydro-pyrido[3,4-c]pyridazine-4-carbonitrile 
• 128763-75-7 4-[(E)-2-(4-Methoxy-phenyl)-vinyl]-6-oxo-1-phenyl-1,6-dihydro-pyridazine-3,5-dicarbonitrile 
• 124315-54-4 6-Oxo-1-phenyl-4-((E)-styryl)-1,6-dihydro-pyridazine-3,5-dicarbonitrile 
• 129811-90-1 1-amino-6,7-dihydro-7-oxo-6-phenylthieno<3,4-d>pyridazine-4-thiocarboxamide 
• 128763-67-7 8-Amino-2,3-dihydro-6-(2-furyl)-3-oxo-2-phenylcinnolin-4,7-dicarbonitrile 
• 128763-65-5 8-Amino-2,3-dihydro-2,6-diphenyl-3-oxocinnolin-4,7-dicarbonitrile 
• 128763-66-6 8-Amino-2,3-dihydro-6-p-methoxyphenyl-3-oxo-2-phenylcinnolin-4,7-dicarbonitrile 
• 128763-76-8 4-((E)-2-Furan-2-yl-vinyl)-6-oxo-1-phenyl-1,6-dihydro-pyridazine-3,5-dicarbonitrile 

Relevant academic research and scientific papers

A microwave assisted diazo coupling reaction: The synthesis of alkylazines and thienopyridazines

Heating diazoaminobenzene with active methylene compounds 1-3 in microwave oven in acetic acid, in the presence of hydrochloric acid, afforded the corresponding arylhydrazones 5-7. These reaction products were condensed with ethyl cyanoacetate in a domestic microwave oven after 1-2 minutes heating to yield the pyridazinones 8-12. Compounds 8c and 12 reacted with sulfur in basic DMF solution, in microwave oven using MORE technology to yield the thienopyridazinone 14 and 16 respectively. While 17 was produced when 8b was treated like wise with sulfur and DMF in the presence of piperidine. Compounds 16 coupled with aromatic diazonium salts to yield arylazo derivatives 21a-c. Copyright Taylor & Francis Group, LLC.

Chemistry of Alkylheterocyclic Aromatic ?-Deficient Compounds: A Novel Synthesis of Cinnolines

A novel synthesis of cinnolines by reacting arylidenemalononitrile derivatives with 1-aryl-1,6-dihydro-6-oxo-pyridazin-3,5-dicarbonitrile is reported.

REACTIONS WITH 3-OXO-2-PHENYLHYDRAZONOBUTYRONITRILR: NEW ROUTES FOR THE SYNTHESIS OF PYRIDAZINES

Several new pyridazine derivatives were synthesized via reaction of β-functionally substituted nitrile 1 with active methylene reagents.The reaction of 1 with 3-methyl-2-pyrazolin-5-one afforded the pyranopyrazole derivative 16.