124368-83-8

Upstream product

• 120390-75-2 (R)-(+)-α-<(tert-butyldimethylsilyl)oxy>-benzeneacetonitrile 
• 492-41-1 (1R,2S)-norephedrine 
• 69739-34-0 t-butyldimethylsiyl triflate 
• 18162-48-6 tert-butyldimethylsilyl chloride 

Downstream Products

• 492-41-1 (1R,2S)-norephedrine 
• 263143-80-2 N-[(1'S,2'R)-2'-tert-butyldimethylsiloxy-1'-methyl-2'-phenylethyl]piperidin-4-one 
• 3198-15-0 (1R,2S)-(-)-norephedrine hydrochloride 
• 1415568-35-2 C₁₇H₂₉NO₂Si 
• 1415568-44-3 C₁₇H₂₆⁽²⁾H₃NO₂Si 
• 138715-28-3 (4S,5R)-(-)-4-Methyl-5-phenyloxazolidine-2-selone 
• 138715-29-4 (4S,5R)-3-<5-(1,2-dithiolan-3-yl)-1-oxopentyl>-4-methyl-5-phenyloxazolidine-2-selone 
• 138715-26-1 (1S,2R)-2-(tert-butyldimethylsiloxy)-1-methyl-2-phenylethyl isocyanide 
• 138715-27-2 (1S,2R)-2-(tert-butyldimethylsiloxy)-1-methyl-2-phenylethyl isoselenocyanate 
• 84025-82-1 (-)-(2R,3S)-3-Methyl-2-phenylmorpholin 

Relevant academic research and scientific papers

Enhanced diastereoselectivity via confinement: Photoisomerization of 2,3-diphenylcyclopropane-1-carboxylic acid derivatives within zeolites

From the perspective of asymmetric induction, the photochemistry of 24 chiral esters and amides of cis-2,3-diphenylcyclopropane-1-carboxylic acid from excited singlet and triplet states has been investigated within zeolites. The chiral auxiliaries placed

Synthesis of chiral amino alcohols embodying the bispidine framework and their application as ligands in enantioselectively catalyzed additions to C=O and C=C groups

Two generally applicable routes for the synthesis of chiral amino alcohols embodying the bispidine framework have been developed. In linear route A the bispidine framework is built up successively from chiral primary amines via intermediate formation of a piperidinone and a bispidinone. In convergent route B an achiral bispidine is formed first and then the N- substituents are introduced by reaction of the nitrogen bases with chiral electrophiles. In order to determine if the bispidine core and its N- substituents can influence the steric course of enantioselective transformations, bispidine amino alcohols built up by these two routes were investigated as chiral ligands in the enantioselectively catalyzed addition of diethylzinc to aldehydes and chalcone. In general, tridentate ligands containing one chiral amino alcohol fragment and a second amino substituent without a stereogenic center were more efficient than tetradentate ligands with two amino alcohol structural units. With the best ligands the enantioselective addition of diethylzinc to aromatic and aliphatic aldehydes proceeded with 83-98% ee and the nickel-catalyzed addition of diethylzinc to chalcone was achieved with up to 85% ee.

Synthesis of (4S,5R)-(-)-4-Methyl-5-phenyloxazolidine-2-selone: A Chiral Auxiliary Reagent Capable of Detecting the Enantiomers of (R,S)-Lipoic Acid by 77Se Nuclear Magnetic Resonance Spectroscopy

(4S,5R)-(-)-4-Methyl-5-phenyloxazolidine-2-selone was constructed in 5 steps on the 10-gram scale. 77Se NMR spectroscopic studies revealed that this selone served as a remarkably sensitive chiral auxiliary agent which readily distinguished the selone-coup