124382-13-4Relevant academic research and scientific papers
Synthesis of aryl α,α-difluoroethyl thioethers a novel structure motif in organic chemistry, and extending to aryl α,α-difluoro oxyethers
Tomita, Ren,Al-Maharik, Nawaf,Rodil, Andrea,Bühl, Michael,O'Hagan, David
, p. 1113 - 1117 (2018/02/22)
A method for the preparation of aryl α,α-difluoroethyl thioethers (ArSCF2CH3) is reported and the synthesis approach is extended to aryl α,α-difluoroethyl oxygen ethers. Selected building blocks are further elaborated in cross-coupli
Reaction of carbonyl compounds with xenon difluoride in the presence of silicon tetrafluoride
Tamura, Masanori,Matsukawa, Yasuhisa,Quan, Heng-Dao,Mizukado, Junji,Sekiya, Akira
, p. 705 - 709 (2007/10/03)
Reaction of various carbonyl compounds with xenon difluoride in the presence of silicon tetrafluoride was investigated. Aromatic aldehyde, ketones, and α-ketoester react with xenon difluoride to give α,α-difluoroalkyl phenyl ethers. However, acid fluoride, ester, acid cyanide, α-ketocarboxylic acid, or thioester do not afford the corresponding products. In the case of cinnamaldehyde, fluorination was accompanied by intramolecular cyclization to afford fluorinated epoxide.
