124391-76-0

Basic information

• Product Name: (S)-1-CBZ-3-HYDROXYMETHYLPYRROLIDINE
• Synonyms: (S)-1-CBZ-3-HYDROXYMETHYLPYRROLIDINE;(S)-1-CBZ-BETA-PROLINOL;S-1-Cbz-3-(Hydroxymethyl)piperidine;(S)-benzyl 3-(hydroxyMethyl)pyrrolidine-1-carboxylate;(S)-1-Cbz-3-(hydroxyMethy...;benzyl (3S)-3-(hydroxymethyl)pyrrolidine-1-carboxylate;(S)-Benzyl-3-(hydroxymethyl)pyrrolidine-1-carboxylate,99%e.e.
• CAS NO: 124391-76-0
• Molecular Formula: C₁₃H₁₇NO₃
• Molecular Weight: 235.28
• Product Categories: pharmacetical
• Mol File: 124391-76-0.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 381.969 °C at 760 mmHg
• Flash Point: 184.809 °C
• Appearance: /
• Density: 1.196 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.561
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (S)-1-CBZ-3-HYDROXYMETHYLPYRROLIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-1-CBZ-3-HYDROXYMETHYLPYRROLIDINE(124391-76-0)
• EPA Substance Registry System: (S)-1-CBZ-3-HYDROXYMETHYLPYRROLIDINE(124391-76-0)

Safety Data

• Hazardous Substances Data: 124391-76-0(Hazardous Substances Data)

Usage

General Description

(S)-1-CBZ-3-HYDROXYMETHYLPYRROLIDINE is a chemical compound that belongs to the class of pyrrolidines. It is a chiral compound with a specific three-dimensional arrangement of atoms, resulting in two mirror-image forms known as enantiomers. (S)-1-CBZ-3-HYDROXYMETHYLPYRROLIDINE has a carbamate (CBZ) functional group and a hydroxymethyl group attached to the third carbon of the pyrrolidine ring. It may have potential applications in organic synthesis and pharmaceutical research due to its unique structure and properties. The precise uses and effects of (S)-1-CBZ-3-HYDROXYMETHYLPYRROLIDINE in various fields are still undergoing investigation.

InChI:InChI=1/C13H17NO3/c15-9-12-6-7-14(8-12)13(16)17-10-11-4-2-1-3-5-11/h1-5,12,15H,6-10H2/t12-/m0/s1

Upstream product

• 192213-99-3 (S)-1-Benzyl-3-benzyloxymethyl-pyrrolidine 
• 192213-98-2 Methanesulfonic acid (R)-2-benzyloxymethyl-4-methanesulfonyloxy-butyl ester 
• 192213-97-1 (S)-2-Benzyloxymethyl-butane-1,4-diol 
• 172796-28-0 (R)-4-((benzyloxy)methyl)dihydrofuran-2(3H)-one 
• 78914-69-9 (S)-(-)-N-benzylpyrrolidine-2-methanol hydrochloride 
• 617-52-7 Dimethyl itakonate 
• 99735-46-3 methyl (3S)-1-<(R)-1-phenylethyl>-5-oxo-3-pyrrolidinecarboxylate 
• 501-53-1 benzyl chloroformate 
• 110013-19-9 (S)-(-)-3-(hydroxymethyl)pyrrolidine 
• 31970-04-4 1-carboxybenzyl-3-pyrrolidine 
• 74-97-5 chlorobromomethane 

Downstream Products

• 72580-53-1 (S)-(+)-3-pyrrolidinecarboxylic acid 
• 847952-27-6 (S)-3-{4-[(S)-5-(Acetylamino-methyl)-2-oxo-oxazolidin-3-yl]-2-fluoro-phenoxymethyl}-pyrrolidine-1-carboxylic acid benzyl ester 
• 648418-11-5 (S)-3-(4-Benzyloxycarbonylamino-2-fluoro-phenoxymethyl)-pyrrolidine-1-carboxylic acid benzyl ester 
• 790702-94-2 N-{(S)-3-[3-Fluoro-4-((S)-1-pyrrolidin-3-ylmethoxy)-phenyl]-2-oxo-oxazolidin-5-ylmethyl}-acetamide 
• 192214-00-9 (S)-1-((benzyloxy)carbonyl)pyrrolidine-3-carboxylic acid 

Relevant articles and documents

A rapid and convenient synthesis of β-proline

A short, reliable, and cheap synthesis of both enantiomers of β-proline, an efficient organocatalyst and an important building block in medicinal chemistry, has been developed in four steps (overall yield: 72%) from the diasteromeric adducts of methyl itaconate and (R)-α-methylbenzylamine. The key step involves the chemoselective reduction of a lactam group in the presence of a benzyl ester.

Ligands for monoamine receptors and transporters, and methods of use thereof

One aspect of the present invention relates to heterocyclic compounds. A second aspect of the present invention relates to the use of the heterocyclic compounds as ligands for various mammalian cellular receptors, including dopamine, serotonin, or norepinephrine transporters. The compounds of the present invention will find use in the treatment of numerous ailments, conditions and diseases which afflict mammals, including but not limited to addiction, anxiety, depression, sexual dysfunction, hypertension, migraine, Alzheimer's disease, obesity, emesis, psychosis, schizophrenia, Parkinson's disease, inflammatory pain, neuropathic pain, Lesche-Nyhane disease, Wilson's disease, and Tourette's syndrome. An additional aspect of the present invention relates to the synthesis of combinatorial libraries of the heterocyclic compounds, and the screening of those libraries for biological activity, e.g., in assays based on dopamine transporters.

CHIRAL SYNTHESIS VIA ORGANOBORANES. 19. THE SUCCESSFUL ONE-CARBON HOMOLOGATION OF HETEROCYCLIC BORONATE ESTERS WITH HIGH OPTICAL PURITY

An exploratory study was undertaken to establish the applicability of the one-carbon homologation to heterocyclic boronic esters.This procedure involves the use of (cloromethyl)lithium, LiCH2Cl, generated in situ by the reaction of bromochloromethane and n-BuLi in THF at -78 deg C in the presence of an enantiomerically pure heterocyclic boronic ester.These heterocyclic boronic esters were prepared via asymmetric hydroboration of representative heterocyclic olefins bearing either an endocyclic or exocyclic double bond with either Ipc2BH or IpcBH2 in THF.