78914-69-9 Usage
Uses
Used in Asymmetric Catalysis:
(S)-1-Benzyl-beta-prolinol is utilized as a ligand in asymmetric catalysis, where it plays a crucial role in enhancing the selectivity of chemical reactions, leading to the preferential formation of one enantiomer over another. This is particularly important in the synthesis of pharmaceutical compounds, where the desired biological activity is often associated with a specific enantiomer.
Used in Organic Synthesis as a Chiral Auxiliary:
In organic synthesis, (S)-1-benzyl-beta-prolinol serves as a chiral auxiliary, providing a source of chirality to influence the stereochemistry of reactions. This is instrumental in the preparation of complex organic molecules with specific spatial arrangements, which is essential for the development of new drugs and other bioactive compounds.
Used in Pharmaceutical Compound Preparation:
(S)-1-Benzyl-beta-prolinol is employed in the preparation of various pharmaceutical compounds, leveraging its chiral properties to facilitate the synthesis of enantiomerically pure drugs. This is vital for ensuring the desired therapeutic effects and minimizing potential side effects associated with the less active or unwanted enantiomer.
Used in the Synthesis of Biologically Active Compounds:
(S)-1-BENZYL-BETA-PROLINOL is also used as a building block for the synthesis of biologically active compounds, contributing to the development of new molecules with potential applications in medicine and other fields.
Used in Disease Treatment Research:
(S)-1-Benzyl-beta-prolinol has been studied for its potential use in the treatment of certain diseases, indicating its versatility and the ongoing exploration of its therapeutic potential beyond its applications in synthesis and catalysis.
Check Digit Verification of cas no
The CAS Registry Mumber 78914-69-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,8,9,1 and 4 respectively; the second part has 2 digits, 6 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 78914-69:
(7*7)+(6*8)+(5*9)+(4*1)+(3*4)+(2*6)+(1*9)=179
179 % 10 = 9
So 78914-69-9 is a valid CAS Registry Number.
InChI:InChI=1/C12H17NO/c14-10-12-6-7-13(9-12)8-11-4-2-1-3-5-11/h1-5,12,14H,6-10H2/t12-/m0/s1
78914-69-9Relevant articles and documents
A chemoenzymatic approach to the synthesis of enantiomerically pure aza analogues of paraconic acid methyl ester and both enantiomers of methyl β-proline
Felluga, Fulvia,Pitacco, Giuliana,Prodan, Massimo,Pricl, Sabrina,Visintin, Marco,Valentin, Ennio
, p. 3241 - 3249 (2007/10/03)
Enantiopure methyl esters of 1-alkyl-5-oxo-3-pyrrolidinecarboxylic acids were obtained by enzymatic resolution of the corresponding chiral racemic mixtures. A particularly favourable interaction, also supported by molecular mechanics calculations, was observed between the 1-benzyl derivative and α-chymotrypsin, for which the enantiomeric ratio, E, exceeded 200. The absolute configurations of the lactams were determined by means of CD spectroscopy. From the resulting enantiomerically pure (99% e.e.) (S)-(+)-1-benzyl-3-pyrrolidinecarboxylic acid and methyl (R)-(-)-1-benzyl-3-pyrrolidinecarboxylate, the methyl esters of (+) and (-)-β-proline were synthesised in 99% e.e. and 18 and 22% overall yield, respectively.
