110013-19-9

Basic information

• Product Name: (S)-Pyrrolidin-3-ylmethanol
• Synonyms: (s)-pyrrolidin-3-ylmethanol;(3S)-3-Pyrrolidinemethanol;(S)-3-Pyrrolidinemethanol;3-(S)-Hydroxymethylpyrrolidine;(S)-pyrrolidin-3-ylmethanol hydrochloride;3-Pyrrolidinemethanol, (S)-;(3S)-pyrrolidin-3-ylMethanol;L-^b-Prolinol, 95%
• CAS NO: 110013-19-9
• Molecular Formula: C₅H₁₁NO
• Molecular Weight: 101.15
• Mol File: 110013-19-9.mol
• Article Data: 28

Chemical Properties

• Melting Point: 174-176℃
• Boiling Point: 176 °C
• Flash Point: 90 °C
• Appearance: /
• Density: 0.978
• Vapor Pressure: 0.339mmHg at 25°C
• Refractive Index: 1.454
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 14.93±0.10(Predicted)
• Water Solubility: Slightly soluble in water
• Sensitive: Hygroscopic
• CAS DataBase Reference: (S)-Pyrrolidin-3-ylmethanol(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-Pyrrolidin-3-ylmethanol(110013-19-9)
• EPA Substance Registry System: (S)-Pyrrolidin-3-ylmethanol(110013-19-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37-60
• TSCA: No
• Hazardous Substances Data: 110013-19-9(Hazardous Substances Data)

Usage

Uses

(S)-Pyrrolidin-3-ylmethanol is used in the preparation of pyridoindoles as kinase inhibiting compounds useful in treatment and prevention of kinase-associated diseases.

InChI:InChI=1/C5H11NO/c7-4-5-1-2-6-3-5/h5-7H,1-4H2/t5-/m0/s1

Upstream product

• 35309-35-4 5-oxopyrrolidine-3-carboxylic acid methyl ester 
• 109960-55-6 (3S)-N-<(R)-phenylethyl>-3-(hydroxymethyl)pyrrolidine 
• 99735-47-4 (3R)-1-[(R)-1-phenylethyl]-3-(hydroxymethyl)pyrrolidine 
• 51535-00-3 methyl 1-benzyl-5-oxo-3-pyrrolidinecarboxylate 
• 96449-93-3 (R)-5-Oxo-1-((S)-1-phenyl-ethyl)-pyrrolidine-3-carboxylic acid 
• 192214-02-1 β-azidomethyl γ-butyrolactone 
• 172796-28-0 (R)-4-((benzyloxy)methyl)dihydrofuran-2(3H)-one 
• 428518-36-9 methyl (R)-(-)-1-(phenylmethyl)-5-oxo-3-pyrrolidinecarboxylate 
• 617-52-7 Dimethyl itakonate 
• 192213-99-3 (S)-1-Benzyl-3-benzyloxymethyl-pyrrolidine 
• 192213-98-2 Methanesulfonic acid (R)-2-benzyloxymethyl-4-methanesulfonyloxy-butyl ester 
• 192213-97-1 (S)-2-Benzyloxymethyl-butane-1,4-diol 
• 428518-42-7 (S)-(+)-1-(phenylmethyl)-5-oxo-3-pyrrolidinecarboxylic acid 
• 78914-69-9 (S)-(-)-N-benzylpyrrolidine-2-methanol hydrochloride 

Downstream Products

• 192214-06-5 (R)-1-((benzyloxy)-carbonyl)pyrrolidine-3-carboxylic acid 
• 1251297-15-0 C₁₂H₁₄N₂O 
• 878013-26-4 (R)-[1-(4-bromophenyl)pyrrolidin-3-yl]methanol 
• 5731-17-9 1-(Phenylmethyl)-3-pyrrolidinemethanol 
• 138108-72-2 tert-butyl (R)-3-hydroxymethylpyrrolidine-1-carboxylate 
• 315718-05-9 benzyl 3-(hydroxymethyl)pyrrolidine-1-carboxylate 
• 1355455-26-3 benzyl 3-{[(methylsulfonyl)oxy]methyl}pyrrolidine-1-carboxylate 
• 1355455-35-4 benzyl 3-[(acetylthio)methyl]pyrrolidine-1-carboxylate 
• 242459-80-9 benzyl 3-[(chlorosulfonyl)methyl]pyrrolidine-1-carboxylate 
• 1307881-21-5 (+/-)-N-carbobenzoxy-3-sulfamoyloxymethylpyrrolidine 
• 1307881-22-6 (+/-)-3-sulfamoyloxymethyl-N-(toluene-4-sulfonyl)pyrrolidine 
• 1017395-94-6 C₁₄H₂₁NO₃ 
• 1593181-83-9 C₂₁H₂₆N₂O₄ 
• 1593181-81-7 C₁₉H₂₂N₂O₂ 

Relevant articles and documents

Discovery of phenylpyrrolidine derivatives as a novel class of retinol binding protein 4 (RBP4) reducers

Retinol-binding protein 4 (RBP4) is a potential drug target for metabolic and ophthalmologic diseases. A high-throughput screening of our compound library has identified a small-molecule RBP4 reducer 7a, as a hit compound. Aiming to provide a suitable too

Method for synthesizing N-Boc-3-pyrrolidine formaldehyde

The invention discloses a method for synthesizing N-Boc-3-pyrrolidine formaldehyde. The method comprises that dimethyl itaconate as a raw material undergoes an intramolecular cyclization reaction to produce methyl 5-oxo-3-pyrrolidine carboxylate, then the methyl 5-oxo-3-pyrrolidine carboxylate undergoes a reduction reaction to produce pyrrolidine-3-methanol, then the pyrrolidine-3-methanol is subjected to Boc protection so that N-Boc-pyrrolidine-3-methanol is obtained, and finally, the N-Boc-pyrrolidine-3-methanol is oxidized to form a final product compound. The method is simple and convenient, has a low cost, content greater than 99%, produces small environmental pollution and is suitable for industrial production.

AURORA KINASE COMPOUNDS AND METHODS OF THEIR USE

Provided herein are pyrrolotriazine compounds for treatment of Aurora kinase mediated diseases. Also provided are pharmaceutical compositions comprising the compounds and methods of using the compounds and compositions.