1243985-07-0Relevant academic research and scientific papers
Iron-Catalyzed Primary C—H Amination of Sulfamate Esters and Its Application in Synthesis of Azetidines?
Zhang, Yan,Zhong, Dayou,Usman, Muhammad,Xue, Peng,Liu, Wen-Bo
, p. 1651 - 1655 (2020)
The direct amination of unactivated primary C—H bonds is extremely challenging due to their inert nature. Herein, we report an intramolecular primary C—H amination of sulfamate esters using an iron catalyst derived from iron(II) triflate and bipyridine. An array of oxathiazinanes were synthesized in moderate to good yields, which were further converted into biologically important azetidines by a one-pot procedure. This research demonstrates the potential of applying simple nitrogen ligands in iron-catalyzed C—H functionalization and offers an accessible alternative to state-of-the-art iron-nitrene chemistry.
Grignard additions to cyclic sulfamidate imines: Synthesis of n-substituted quaternary sulfamidate building blocks
Chang, Stanley,Lee, Ernest E.
scheme or table, p. 2361 - 2366 (2010/09/08)
The addition of Grignard reagents to cyclic sulfamidate imines has been developed as a facile method for the synthesis of N-substituted quaternary sulfamidates. By way of ring opening with an appropriate nucleophile, versatile synthons for 1,2-amino alcohols, 1,2-diamines, and β-amino acids are produced. Georg Thieme Verlag Stuttgart · New York.
