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Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
3-Fluoro-2-hydroxyquinoline is used as a key intermediate in the synthesis of pharmaceuticals and agrochemicals. Its unique structure and properties contribute to the development of new drugs and pesticides with improved efficacy and safety.
Used in Antimicrobial Agents Development:
3-Fluoro-2-hydroxyquinoline exhibits antibacterial and antifungal properties, making it a potential candidate for the development of new antimicrobial agents. Its ability to target and inhibit the growth of harmful microorganisms can lead to the creation of more effective treatments for various infections.
Used in Fluorescent Probes for Metal Ion Detection:
3-Fluoro-2-hydroxyquinoline is studied for its potential as a fluorescent probe for detecting the presence of metal ions in biological systems. Its fluorescence properties can be utilized to monitor and analyze metal ion concentrations, which is crucial for understanding their role in biological processes and potential health implications.

Upstream product

• 2338-72-9 3-fluoroquinoline 1-oxide 
• 175609-72-0 (Z)-2-fluoro-3-methoxyprop-2-enanilide 
• 62-53-3 aniline 

Downstream Products

• 834883-99-7 2-bromo-3-fluoroquinoline 
• 834884-07-0 3-fluoroquinoline-2-carboxylic acid 

Relevant academic research and scientific papers

3-fluoro-2-quinolones from anilines

N-(Fluoro-3-methoxyacryloyl)anilines [2-fluoro-3-methoxyprop-2-enanilides] can be prepared by condensation between lithium anilides and methyl 2-fluoro-3-methoxyprop-2-enoate. Under strongly acidic conditions, these intermediate undergo a cyclization reac

The tautomeric persistence of electronically and sterically biased 2-quinolinones

One dozen of tailormade model 3-fluoro-2(1H)-quinolinones were synthesized in order to be investigated by UV-, IR- and NMR spectroscopic techniques. All of these compounds were found to exist predominantly, if not exclusively, in the lactam (carboxamide,

Metalated Fluoropyridines and Fluoroquinolines as Reactive Intermediates: New Ways for Their Regioselective Generation

The mixture of lithium diisopropylamide and potassium tert-butoxide ("LIDA-KOR reagent") is a powerful base which can be advantageously employed for the regioselective deprotonation of fluoropyridines and, in particular, 3-fluoroquinoline.A novel cyclization process was elaborated for the preparation of the latter product.

REACTIONS OF 3-SUBSTITUTED QUINOLINE 1-OXIDES WITH ACYLATING AGENTS

Reactions of 3-fluoro- (1a), 3-bromo- (1b), 3-methyl- (1c), 3-methoxy- (1d) and 3-acetamidoquinoline 1-oxides (1e) with acylating agents (POCl3, Ac2O, TsCl and PhCOCl) were examined (Table).While only 2-substituted quinolines were obtained from 1a and 1b, fair amounts of 4-substituted products were formed in reactions of 1d, the sole formation of the 4-acetoxyquinoline (6) with Ac2O being the most significant result. 2-Chloroquinolines, 4-chloroquinolines and 2-tosyloxyquinolines were formed (and sometimes predominate) in addition to 2-quinolinones in reactions with TsCl.