124492-17-7Relevant academic research and scientific papers
Silver sequestration of halides for the activation of Pd(OAc)2 catalyzed Mizoroki-Heck reaction of 1,1 and 1,2 - Disubstituted alkenes
Bangar, Pronnoy G.,Jawalkar, Priyanka R.,Dumbre, Swapnil R.,Patil, Dharmaraj J.,Iyer, Suresh
, (2018)
A ligand free catalytic system consisting of Pd(OAc)2 (cat) and stoichiometric quantities of silver salts, AgOAc or AgBF4, exhibit high efficiency in the Mizoroki-Heck arylation, transforming aryl iodides and 1,1 as well as 1,2 disubstituted alkenes into 1,1,2 – trisubstituted aryl alkenes in excellent yields in very short reaction times.
CONJUGATE ADDITION VS. VINYLIC SUBSTITUTION IN PALLADIUM-CATALYSED REACTION OF ARYL HALIDES WITH β-SUBSTITUTED-α,β-ENONES AND -ENALS
Amorese, A.,Arcadi, A.,Bernocchi, E.,Cacchi, S.,Cerrini, S.,et al.
, p. 813 - 828 (2007/10/02)
The reaction of β-substituted-α,β-enones and -enals with aryl halides in the presence of a palladium catalyst has been investigated.The outcome of the reaction was found to be greatly dependent on the nature of the added base.Tertiary amines tend to favour the formation of conjugate addition-type products while sodium bicarbonate or sodium acetate that of vinylic substitution products.Usually, the use of sodium acetate produced results comparable or better than those obtained with sodium bicarbonate.Furthermore, in the reaction of aryl halides containing strongly electron-withdrawing groups, sodium acetate afforded a dramatic increase in the yield of vinylic substitution products.
