1244949-62-9

Basic information

• Product Name: 2-chloro-4-(cyclopentylamino)-5-pyrimidinyl ethanone
• Synonyms: 2-chloro-4-(cyclopentylamino)-5-pyrimidinyl ethanone;1-(2-chloro-4-(cyclopentylamino)pyrimidin-5-yl)ethan-1-one
• CAS NO: 1244949-62-9
• Molecular Formula: C11H14ClN3O
• Molecular Weight: 239.70136
• EINECS: -0
• Mol File: 1244949-62-9.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 442.1±30.0 °C(Predicted)
• Appearance: /
• Density: 1.305±0.06 g/cm3(Predicted)
• PKA: 0.84±0.10(Predicted)
• CAS DataBase Reference: 2-chloro-4-(cyclopentylamino)-5-pyrimidinyl ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-4-(cyclopentylamino)-5-pyrimidinyl ethanone(1244949-62-9)
• EPA Substance Registry System: 2-chloro-4-(cyclopentylamino)-5-pyrimidinyl ethanone(1244949-62-9)

Safety Data

• Hazardous Substances Data: 1244949-62-9(Hazardous Substances Data)

Usage

Uses

1-[2-Chloro-4-(cyclopentylamino)-5-pyrimidinyl]ethanone acts as a reagent for the preparation of Palbociclib, a drug for the treatment of ER-positive and HER-negative breast cancer development.

Upstream product

• 75-05-8 acetonitrile 
• 1003-03-8 Cyclopentamine 

Downstream Products

• 571188-82-4 tert?butyl 4?(6?((6?bromo?8?cyclopentyl?5?methyl?7?oxo?7,8?dihydropyrido[2,3?d]pyrimidin?2?yl)amino)pyridin?3?yl)piperazine?1?carboxylate 
• 1651214-74-2 4-[6-(6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-ylamino)pyridine-3-yl]piperazine-1-carboxylic acid tert-butyl ester 
• 1016636-76-2 2-chloro-5-methyl-6-bromo-8-cyclopentylpyridine[2,3-d]pyrimidin-8-hydro-7-one 
• 571189-03-2 8-cyclopentyl-2-[[5-[4-[(1,1-dimethylethoxy)carbonyl]-1-piperazinyl]-2-pyridinyl]amino]-7,8-dihydro-5-methyl-7-oxo-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester 

Relevant articles and documents

Novel synthetic method of Palbociclib

The invention provides a novel synthetic method of Palbociclib, comprising the following steps: 1) under the action of alkali and a solvent, an intermediate V and an intermediate B1 undergo a condensation reaction to obtain a compound VI; 2) the compound VI undergoes exchange with a Grignard reagent, and then the exchange reaction product reacts with an acylation reagent to obtain a compound VII; when X is acetyl, the compound VI is the compound VII; 3) the compound VII undergoes deprotection reaction under the action of hydroxyethanesulphonic acid and finally salification is conducted so as to obtain the finished product Palbociclib X. the synthetic method has a simple process route, is low-cost, and is suitable for industrial production. The synthetic route is as shown in the specification.