112898-33-6

Basic information

• Product Name: TRANS-2,5-DIFLUOROCINNAMIC ACID
• Synonyms: (2E)-3-(2,5-Difluorophenyl)-2-propenoic acid;2,5-DIFLUOROCINNAMIC ACID;TRANS-2,5-DIFLUOROCINNAMIC ACID;RARECHEM AL BK 0214;trans-2,5-Difluorocinnamic acid 97%;trans-2,5-Difluorocinnamicacid97%;(2E)-3-(2,5-Difluorophenyl)acrylic acid, trans-3-(2,5-Difluorophenyl)prop-2-enoic acid;trans-2,5-Difluorociamic acid,98%
• CAS NO: 112898-33-6
• Molecular Formula: C₉H₆F₂O₂
• Molecular Weight: 184.14
• Product Categories: Fluoro-contained cinnamic acid series;Aromatic Cinnamic Acids, Esters and Derivatives;Cinnamic acid;Miscellaneous;Acids & Esters;Fluorine Compounds;C9;Carbonyl Compounds;Carboxylic Acids;Fluorine series
• Mol File: 112898-33-6.mol
• Article Data: 3

Chemical Properties

• Melting Point: 138-140 °C(lit.)
• Boiling Point: 278.5°Cat760mmHg
• Flash Point: 122.2°C
• Appearance: /
• Density: 1.3056 (estimate)
• Vapor Pressure: 0.00204mmHg at 25°C
• PKA: 4.16±0.10(Predicted)
• BRN: 7918450
• CAS DataBase Reference: TRANS-2,5-DIFLUOROCINNAMIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: TRANS-2,5-DIFLUOROCINNAMIC ACID(112898-33-6)
• EPA Substance Registry System: TRANS-2,5-DIFLUOROCINNAMIC ACID(112898-33-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-26/37/39
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 112898-33-6(Hazardous Substances Data)

Usage

Chemical Properties

white crystalline powder

Uses

trans-2,5-Difluorocinnamic acid may be used in chemical synthesis.

InChI:InChI=1/C9H6F2O2/c10-7-2-3-8(11)6(5-7)1-4-9(12)13/h1-5H,(H,12,13)/p-1/b4-1+

Upstream product

• 110-89-4 piperidine 
• 2646-90-4 2,5-difluorobenzaldehyde 
• 399-94-0 2-bromo-1,4-difluorobenzene 
• 79-10-7 acrylic acid 

Downstream Products

• 701914-04-7 3-(2,5-difluoro-phenyl)-N-methoxy-N-methyl-acrylamide 
• 558465-84-2 benzyl 3-(2,5-difluorophenyl)acrylate 
• 917343-02-3 tert-butyl {1-[(2E)-3-(2,5-difluorophenyl)prop-2-en-1-yl]piperidin-4-yl}carbamate 
• 917342-17-7 2-(2,5-difluorophenyl)cyclopropanecarbaldehyde 
• 149946-42-9 2-[(1E)-3-chloroprop-1-en-1-yl]-1,4-difluorobenzene 
• 1073495-60-9 (1R)-1-[(4-{[(2E)-3-(2,5-difluorophenyl)-2-propen-1-yl]amino}-1-piperidinyl)methyl]-9-fluoro-1,2-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one 
• 872263-26-8 (E)-3-(2,5-difluorophenyl)acrylaldehyde 
• 946000-03-9 trans-tert-butyl {4-[[5-(2-carbamoyl-pyridin-4-yl)-2-methoxy-benzyl]-(3-chloro-4,7-difluoro-benzo[b]thiophene-2-carbonyl)-amino]-cyclohexyl}-methyl-carbamate 
• 946000-09-5 trans-tert-butyl (4-{(3-chloro-4,7-difluoro-benzo[b]thiophene-2-carbonyl)-[2-methoxy-5-(2-methylcarbamoyl-pyridin-4-yl)-benzyl]-amino}-cyclohexyl)-methyl-carbamate 
• 946000-20-0 trans-tert-butyl (4-{(3-chloro-4,7-difluoro-benzo[b]thiophene-2-carbonyl)-[5-(2-dimethylcarbamoyl-pyridin-4-yl)-2-methoxy-benzyl]-amino}-cyclohexyl)-methyl-carbamate 
• 946000-01-7 trans-methyl 4-(3-{[[4-(tert-butoxycarbonyl-methyl-amino)-cyclohexyl]-(3-chloro-4,7-difluoro-benzo[b]thiophene-2-carbonyl)-amino]-methyl}-4-methoxy-phenyl)-pyridine-2-carboxylate 
• 1025061-31-7 trans-{4-[[5-(2-acetyl-pyridin-4-yl)-2-methoxy-benzyl]-(3-chloro-4,7-difluoro-benzo[b]thiophene-2-carbonyl)-amino]-cyclohexyl}-methyl-carbamic acid tert-butyl ester 
• 945996-98-5 trans-3-{[[4-(Boc-methyl-amino)-cyclohexyl]-(3-chloro-4,7-difluoro-benzo[b]thiophene-2-carbonyl)-amino]-methyl}-4-methoxy-benzeneboronic acid 

Relevant articles and documents

Small organic molecule regulators of cell proliferation

The present invention makes available methods and reagents for modulating proliferation or differentiation in a cell or tissue comprising contacting the cell with a hedgehog agonist, such as the compounds depicted in FIGS. 32 and 33. In certain embodiments, the methods and reagents may be employed to correct or inhibit an aberrant or unwanted growth state, e.g., by antagonizing a normal ptc pathway or agonizing smoothened or hedgehog activity.

Synthesis of Fluorine-Substituted Cinnamic Acids by Cross-Coupling of Fluorobenzenes with Acrylic Acid in the Presence of a Palladium Catalyst

-