1245187-77-2Relevant academic research and scientific papers
[3 + 2]-Cycloadditions of Azomethine Imines and Ynolates
Winterton, Sarah E.,Ready, Joseph M.
, p. 2608 - 2611 (2016/06/15)
A novel [3 + 2]-cycloaddition between azomethine imines and lithium ynolates is described to synthesize bicyclic pyrazolidinones. These bicyclic pyrazolidinones are versatile intermediates to form β-amino acids and monocyclic pyrazolidinones. High diaster
Enantioselective Nucleophilic β-Carbon-Atom Amination of Enals: Carbene-Catalyzed Formal [3+2] Reactions
Wu, Xingxing,Liu, Bin,Zhang, Yuexia,Jeret, Martin,Wang, Honglin,Zheng, Pengcheng,Yang, Song,Song, Bao -An,Chi, Yonggui Robin
, p. 12280 - 12284 (2016/10/13)
An enantioselective β-carbon amination for enals is disclosed. The nitrogen atom from a protected hydrazine with suitable electronic properties readily behaves as a nucleophile. Addition of the nitrogen nucleophile to a catalytically generated N-heterocyclic-carbene-bound α,β-unsaturated acyl azolium intermediate constructs a new carbon–nitrogen bond asymmetrically. The pyrazolidinone products from our catalytic reactions are common scaffolds in bioactive molecules, and can be easily transformed into useful compounds such as β3-amino-acid derivatives.
Rhodium-catalyzed asymmetric arylation of azomethine imines
Shintani, Ryo,Soh, Ying-Teck,Hayashi, Tamio
supporting information; experimental part, p. 4106 - 4109 (2010/11/19)
A rhodium-catalyzed addition of sodium tetraarylborates to azomethine imines has been described. Highly efficient asymmetric catalysis has also been achieved by employing a chiral diene ligand to give 1-(diarylmethyl)pyrazolidin- 3-ones with high enantioselectivity.
