669087-29-0Relevant academic research and scientific papers
Enantioselective Nucleophilic β-Carbon-Atom Amination of Enals: Carbene-Catalyzed Formal [3+2] Reactions
Wu, Xingxing,Liu, Bin,Zhang, Yuexia,Jeret, Martin,Wang, Honglin,Zheng, Pengcheng,Yang, Song,Song, Bao -An,Chi, Yonggui Robin
, p. 12280 - 12284 (2016/10/13)
An enantioselective β-carbon amination for enals is disclosed. The nitrogen atom from a protected hydrazine with suitable electronic properties readily behaves as a nucleophile. Addition of the nitrogen nucleophile to a catalytically generated N-heterocyclic-carbene-bound α,β-unsaturated acyl azolium intermediate constructs a new carbon–nitrogen bond asymmetrically. The pyrazolidinone products from our catalytic reactions are common scaffolds in bioactive molecules, and can be easily transformed into useful compounds such as β3-amino-acid derivatives.
Highly enantioselective enzymatic resolution of aromatic β-amino acid amides with Pd-catalyzed racemization
Kim, Mahn-Joo,Choi, Eunjeong,Kim, Yunwoong,Ahn, Yangsoo,Park, Jaiwook
, p. 1449 - 1452 (2013/12/04)
The kinetic resolution of an aromatic β-amino acid amide 3a-d via N-acylation was explored with two lipases, Candida antarctica lipase A (CALA) and Pseudomonas stutzeri lipase (PSL). The PSL-catalyzed resolution proceeded with excellent enantioselectivity
Enantioselective biocatalytic hydrolysis of β-aminonitriles to β-amino-amides using Rhodococcus rhodochrous ATCC BAA-870
Chhiba, Varsha,Bode, Moira L.,Mathiba, Kgama,Kwezi, Wendy,Brady, Dean
, p. 68 - 74 (2012/04/10)
A range of β-aminonitriles (3-amino-3-phenylpropanenitrile and derivatives) were synthesised by reaction of various benzonitriles with acetonitrile and subsequent reduction of the resulting acrylonitrile products. These compounds were hydrolysed to the co
OXYTOCIN INHIBITORS
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Page 101, (2010/02/06)
This invention relates to compounds of formula (I).
