1245285-73-7Relevant academic research and scientific papers
Precise engineering of multifunctional PE gylated polyester nanoparticles for cancer cell targeting and imaging
MacKiewicz, Nicolas,Nicolas, Julien,Handke, Nadege,Noiray, Magali,Mougin, Julie,Daveu, Cyril,Lakkireddy, Harivardhan Reddy,Bazile, Didier,Couvreur, Patrick
, p. 1834 - 1847 (2014)
Multifunctional poly(ethylene glycol)-block-poly(lactic acid) (PEG-b-PLA) nanoparticles for cancer cell targeting and imaging have been designed by a combination of ring-opening polymerization and "click" chemistry. Nanoparticles containing both a targeting ligand and a fluorescent probe were prepared by blending PLA-b-PEG-ligand, PLA-b-PEG-fluorescent probe, and PLA-b-PEG-OMe copolymers at the molar ratios necessary to achieve the desired surface ligand and fluorescent probe densities. This strategy has been illustrated by the preparation of a large library of a variety of nanoparticles, such as ligand-decorated nanoparticles (with biotin, folic acid or anisamide), fluorescent nanoparticles (UV-vis or near-infrared dyes), and multifunctional nanoparticles decorated with a targeting ligand and a fluorescent probe. Successful targeting was demonstrated by surface plasmon resonance and in vitro experiments on different cancer cell lines.
