124530-94-5Relevant academic research and scientific papers
Stereogenic: Cis -2-substituted- N -acetyl-3-hydroxy-indolines via ruthenium(ii)-catalyzed dynamic kinetic resolution-asymmetric transfer hydrogenation
Luo, Zhonghua,Sun, Guodong,Zhou, Zihong,Liu, Guozhu,Luan, Baolei,Lin, Yicao,Zhang, Lei,Wang, Zhongqing
supporting information, p. 13503 - 13506 (2018/12/12)
Ruthenium(ii)-catalyzed dynamic kinetic resolution-asymmetric transfer hydrogenation of racemic 2-substituted-N-acetyl-3-oxoindolines to cis-2-substituted-N-acetyl-3-hydroxyindolines is reported. Using the homochiral {Ru[TfDPEN](p-cymene)} catalyst with S/C = 400 in a HCO2H/Et3N mixture, up to >99.9% ee and >99:1 dr are obtained with high yields (79-98%). This method provides the first example of preparing enantiomerically pure indolines through asymmetric transfer hydrogenation (ATH).
Convenient Procedure for the Synthesis of 2-Monoalkylated Indol-3-ones
Kawasaki, Tomomi,Nonaka, Yoshinori,Kobayashi, Masahiko,Sakamoto, Masanori
, p. 2445 - 2448 (2007/10/02)
2-Alkyl-1,2-dihydroindol-3-ones are prepared from readily available 1-acetyl-2-methoxy-1,2-dihydroindol-3-one by alkylation, reduction with sodium borohydride, and demethoxylation of the resulting 3-hydroxy-2-methoxy-2,3-dihydroindoles with Lewis acids.Th
Synthesis and Reactions of 1-Acetyl-2-benzylidene-3-oxo-2,3-dihydroindoles
Buzas, A.,Merour, J. Y.
, p. 458 - 461 (2007/10/02)
1-Acetyl-3-oxo-2,3-dihydroindoles were reacted with substituted benzaldehydes affording 1-acetyl-2-arylmethylene-3-oxo-2,3-dihydroindoles which were selectively reduced by hydrogen; then a Horner-Emmons reaction gave the precursors of 2-substituted trypta
