1245641-24-0Relevant academic research and scientific papers
Nanoparticles to Study Lectins in Caenorhabditis elegans: Multivalent Galactose β1-4 Fucose-Functionalized Dendrimers Provide Protection from Oxidative Stress
Vankoten, Harrison W.,Moore, Rebecca S.,Cloninger, Mary J.
, p. 4720 - 4729 (2021/11/17)
Galectins are galactoside-binding lectins that are functional dimers or higher-order oligomers. Multivalent binding has been shown to augment the relatively low affinity of the galectins for their galactoside-binding partners, enabling the galectins to pl
Synthesis of fluorescence-labeled galβ1-3Fuc and Galβ1-4Fuc as Probes for the endogenous glyco-epitope recognized by galectins in caenorhabditis elegans
Nishiyama, Kazusa,Yamada, Atsushi,Takahashi, Miki,Takeuchi, Tomoharu,Kasai, Ken-Ichi,Kobayashi, Susumu,Natsugari, Hideaki,Takahashi, Hideyo
experimental part, p. 495 - 500 (2010/08/19)
To search for the endogenous glyco-epitope in Caenorhabditis elegans, we synthesized labeled Galβ1-3Fuc and Galβ1-4Fuc and examined their binding affinity for C. elegans galectin LEC-6 using frontal affinity chromatography analysis. We developed a new strategy for synthesizing the labeled saccharides, in which the labeling unit, the 2-aminopyridine moiety, is coupled with a spacer unit derived from D-mannitol. Our results indicate that Galβ1-4Fuc is the endogenous glyco-epitope present in C. elegans N-glycans.
