1245644-73-8

Basic information

• Product Name: 6-Nitropyrrolo[2,1-f][1,2,4]triazine-2,4(1H,3H)-dione
• Synonyms: 6-Nitropyrrolo[2,1-f][1,2,4]triazine-2,4(1H,3H)-dione;6-Nitro-pyrrolo[2,1-f][1,2,4]triazine-2,4-dione;6-nitro-1H-pyrrolo[2,1-f][1,2,4]triazine-2,4-dione
• CAS NO: 1245644-73-8
• Molecular Formula: C₆H₄N₄O₄
• Molecular Weight: 196.12036
• Mol File: 1245644-73-8.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Density: 2.12±0.1 g/cm3(Predicted)
• PKA: 3.49±0.20(Predicted)
• CAS DataBase Reference: 6-Nitropyrrolo[2,1-f][1,2,4]triazine-2,4(1H,3H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Nitropyrrolo[2,1-f][1,2,4]triazine-2,4(1H,3H)-dione(1245644-73-8)
• EPA Substance Registry System: 6-Nitropyrrolo[2,1-f][1,2,4]triazine-2,4(1H,3H)-dione(1245644-73-8)

Safety Data

• Hazardous Substances Data: 1245644-73-8(Hazardous Substances Data)

Upstream product

• 1263420-13-8 methyl 1-amino-4-nitro-1H-pyrrole-2-carboxylate 
• 13138-74-4 methyl 4-nitropyrrole-2-carboxylate 
• 53391-50-7 2,2,2-trichloro-1-(4-nitro-1H-pyrrol-2-yl)ethan-1-one 
• 35302-72-8 pyrrol-2-yl trichloromethyl ketone 
• 1204245-51-1 ethyl 1-amino-4-nitro-1H-pyrrole-2-carboxylate 
• 5930-92-7 Ethyl 4-nitropyrrole-2-carboxylate 
• 1204245-52-2 1-amino-4-nitro-1H-pyrrole-2-carboxamide 
• 541-41-3 chloroformic acid ethyl ester 

Downstream Products

• 1315585-12-6 N-(2-(4-(cyclopropanecarboxamido)phenylthio)-4-(5-methyl-1H-pyrazol-3-ylamino)pyrrolo[2,1-f][1,2,4]triazin-6-yl)-4-methylpiperazine-1-carboxamide 
• 1315585-24-0 N-(4-((6-(3-(piperidin-1-yl)propanamido)-4-(5-methyl-1H-pyrazol-3-ylamino)pyrrolo[2,1-f][1,2,4]triazin-2-yl)sulfanyl)phenyl)cyclopropanecarboxamide 
• 1160995-45-8 2,4-dichloro-6-nitropyrrolo[2,1-f][1,2,4]triazine 
• 1315587-55-3 N-(4-(4-(5-methyl-1H-pyrazol-3-ylamino)-6-nitropyrrolo[2,1-f][1,2,4]triazin-2-ylthio)phenyl)cyclopropanecarboxamide 
• 1334320-78-3 C₂₀H₂₀N₈OS 
• 1315587-58-6 N-(4-(6-(2-bromoacetamido)-4-(5-methyl-1H-pyrazol-3-ylamino)pyrrolo[2,1-f][1,2,4]triazin-2-ylthio)phenyl)cyclopropanecarboxamide 
• 1315585-02-4 N-(2-(4-acetamidophenylthio)-4-(5-methyl-1H-pyrazol-3-ylamino)pyrrolo[2,1-f][1,2,4]triazin-6-yl)-2-(piperidin-1-yl)acetamide 
• 1315587-60-0 (R)-N-(4-((6-(2-(2-(hydroxymethyl)pyrrolidin-1-yl)acetamido)-4-((5-methyl-1H-pyrazol-3-yl)amino)pyrrolo[2,1-f][1,2,4]triazin-2-yl)thio)phenyl)cyclopropanecarboxamide 
• 1315587-65-5 N-(4-((4-((5-methyl-1H-pyrazol-3-yl)amino)-6-(2-(pyrrolidin-1-yl)acetamido)pyrrolo[2,1-f][1,2,4]triazin-2-yl)thio)phenyl)cyclopropanecarboxamide 
• 1315587-63-3 N-(4-((4-((5-methyl-1H-pyrazol-3-yl)amino)-6-(2-morpholinoacetamido)pyrrolo[2,1-f][1,2,4]triazin-2-yl)thio)phenyl)cyclopropanecarboxamide 

Relevant articles and documents

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The synthesis and SAR for a novel series of pyrrolotriazines as pan-Aurora kinase inhibitors are described. Optimization of the cyclopropane carboxamide terminus of lead compound 1 resulted in analogs with high cellular activity and improved rat PK profiles. Notably, compound 17l demonstrated tumor growth inhibition in a mouse xenograft model.