1315587-65-5

Basic information

• Product Name: N-(4-((4-((5-methyl-1H-pyrazol-3-yl)amino)-6-(2-(pyrrolidin-1-yl)acetamido)pyrrolo[2,1-f][1,2,4]triazin-2-yl)thio)phenyl)cyclopropanecarboxamide
• CAS NO: 1315587-65-5
• Molecular Weight: 531.641
• Mol File: 1315587-65-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-(4-((4-((5-methyl-1H-pyrazol-3-yl)amino)-6-(2-(pyrrolidin-1-yl)acetamido)pyrrolo[2,1-f][1,2,4]triazin-2-yl)thio)phenyl)cyclopropanecarboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-((4-((5-methyl-1H-pyrazol-3-yl)amino)-6-(2-(pyrrolidin-1-yl)acetamido)pyrrolo[2,1-f][1,2,4]triazin-2-yl)thio)phenyl)cyclopropanecarboxamide(1315587-65-5)
• EPA Substance Registry System: N-(4-((4-((5-methyl-1H-pyrazol-3-yl)amino)-6-(2-(pyrrolidin-1-yl)acetamido)pyrrolo[2,1-f][1,2,4]triazin-2-yl)thio)phenyl)cyclopropanecarboxamide(1315587-65-5)

Safety Data

• Hazardous Substances Data: 1315587-65-5(Hazardous Substances Data)

Upstream product

• 1334320-78-3 C₂₀H₂₀N₈OS 
• 1315587-55-3 N-(4-(4-(5-methyl-1H-pyrazol-3-ylamino)-6-nitropyrrolo[2,1-f][1,2,4]triazin-2-ylthio)phenyl)cyclopropanecarboxamide 
• 1315587-54-2 2-chloro-N-(5-methyl-1H-pyrazol-3-yl)-6-nitropyrrolo[2,1-f][1,2,4]triazin-4-amine 
• 1160995-45-8 2,4-dichloro-6-nitropyrrolo[2,1-f][1,2,4]triazine 
• 1245644-73-8 6-nitropyrrolo[2,1-f][1,2,4]triazine-2,4(1H,3H)-dione 
• 1204245-52-2 1-amino-4-nitro-1H-pyrrole-2-carboxamide 
• 123-75-1 pyrrolidine 
• 1315587-58-6 N-(4-(6-(2-bromoacetamido)-4-(5-methyl-1H-pyrazol-3-ylamino)pyrrolo[2,1-f][1,2,4]triazin-2-ylthio)phenyl)cyclopropanecarboxamide 

Relevant articles and documents

Novel series of pyrrolotriazine analogs as highly potent pan-Aurora kinase inhibitors

The synthesis and SAR for a novel series of pyrrolotriazines as pan-Aurora kinase inhibitors are described. Optimization of the cyclopropane carboxamide terminus of lead compound 1 resulted in analogs with high cellular activity and improved rat PK profiles. Notably, compound 17l demonstrated tumor growth inhibition in a mouse xenograft model.