124569-82-0

Upstream product

• 110-00-9 furan 
• 40136-21-8 2,5-diphenylpenta-2,4-dienoic acid 
• 124244-39-9 2-phenyl-2,5-dihydrofuran 
• 33732-62-6 2-phenyl-2,3-dihydrofuran 
• 369-57-3 benzenediazonium tetrafluoroborate 
• 79389-15-4 [1-(prop-2-enyloxy)prop-2-enyl]benzene 

Downstream Products

• 91733-25-4 3,4-dibromo-2,5-bis-(4-bromo-phenyl)-furan 
• 955-83-9 2,5-diphenylfuran 

Relevant academic research and scientific papers

Ru- and Pd-catalysed synthesis of 2-arylfurans by one-flask heck arylation/oxidation

2,5-Disubstituted furans were synthesized by one-flask Heck arylation/oxidation sequences. The starting materials are 2-substituted 2,3-dihydrofurans, conveniently available by RCM/isomerization sequences, and arenediazonium salts. These react in ligand-free Heck reactions to afford 2,5-disubstituted 2,5-dihydrofurans, which are oxidized to the corresponding furans without isolation or intermediate workup. The oxidation is conveniently achieved with chloranil or DDQ, depending on the substrate.

Synthesis of 2,5-dihydro-2,5-diphenylfuran

2,5-Dihydro-2,5-diphenylfuran (4) has been synthesized by the reaction of phenylmagnesium bromide with 2,5-dibromo-2,5-dihydrofuran (3).Reaction of 2,5-dihydro-2,5-dimethoxyfuran (1) with phenylmagnesium bromide and phenyllithium however leads to ring ope