40136-21-8

Basic information

• Product Name: (2Z,4E)-2,5-diphenylpenta-2,4-dienoic acid
• CAS NO: 40136-21-8
• Molecular Formula: C₁₇H₁₄O₂
• Molecular Weight: 250.2919
• Mol File: 40136-21-8.mol

Chemical Properties

• Boiling Point: 443.8°C at 760 mmHg
• Flash Point: 334.5°C
• Density: 1.17g/cm³
• Vapor Pressure: 1.18E-08mmHg at 25°C
• Refractive Index: 1.648
• CAS DataBase Reference: (2Z,4E)-2,5-diphenylpenta-2,4-dienoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (2Z,4E)-2,5-diphenylpenta-2,4-dienoic acid(40136-21-8)
• EPA Substance Registry System: (2Z,4E)-2,5-diphenylpenta-2,4-dienoic acid(40136-21-8)

Safety Data

• Hazardous Substances Data: 40136-21-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
(2Z,4E)-2,5-diphenylpenta-2,4-dienoic acid serves as a key intermediate in the synthesis of various pharmaceuticals. Its unique structure and functional groups make it a valuable building block for developing new drugs with potential therapeutic applications.
Used in Materials Science:
In the field of materials science, (2Z,4E)-2,5-diphenylpenta-2,4-dienoic acid has been investigated for its potential use in creating novel materials with specific properties. Its structural features may contribute to the development of advanced materials for various industrial applications.
Used as a Precursor in Organic Chemical Synthesis:
(2Z,4E)-2,5-diphenylpenta-2,4-dienoic acid is utilized as a precursor in organic chemical synthesis, allowing for the creation of a wide range of organic compounds. Its versatility in reactions makes it an important component in the synthesis of complex organic molecules.
Used in Biological Research:
Due to its anti-inflammatory and antioxidant properties, (2Z,4E)-2,5-diphenylpenta-2,4-dienoic acid is used in biological research to study the mechanisms of inflammation and oxidative stress. This research can lead to a better understanding of various diseases and the development of new treatments.

Upstream product

• 38447-05-1 (2E,4E)-methyl 5-phenylpenta-2,4-dienoate 
• 100-34-5 benzene diazonium chloride 
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• 103-82-2 phenylacetic acid 
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• 163188-49-6 N-m-tolyl-α-phenylstyrylacrylohydroxamic acid 
• 163188-50-9 N-p-chlorophenyl-α-phenylstyrylacrylohydroxamic acid 
• 163188-52-1 N-p-bromophenyl-α-phenylstyrylacrylohydroxamic acid 
• 163188-47-4 N-phenyl-α-phenylstyrylacrylohydroxamic acid 
• 91-66-7 N,N-diethylaniline 

Downstream Products

• 879553-85-2 5-benzyl-3-phenyl-dihydro-furan-2-one 
• 64516-62-7 2,5-diphenyl-pent-2-enoic acid 
• 77670-52-1 (E)-2,5-diphenylpent-2-en-4-ynoic acid 
• 124569-82-0 2,5-dihydro-2,5-diphenylfuran 
• 163188-49-6 N-m-tolyl-α-phenylstyrylacrylohydroxamic acid 
• 163188-50-9 N-p-chlorophenyl-α-phenylstyrylacrylohydroxamic acid 
• 163188-52-1 N-p-bromophenyl-α-phenylstyrylacrylohydroxamic acid 
• 163188-47-4 N-phenyl-α-phenylstyrylacrylohydroxamic acid 
• 124-38-9 carbon dioxide 
• 886-65-7 trans,trans-1,4-Diphenyl-1,3-butadiene 
• 61208-80-8 1,4-Dinitro-1,4-diphenyl-1,3-butadiene 
• 233758-34-4 α-phenylstyrylacryl chloride 

Relevant articles and documents

Novel cinnamic acid derivatives as antioxidant and anticancer agents: Design, synthesis and modeling studies

Cinnamic acids have been identified as interesting compounds with antioxidant, anti-inflammatory and cytotoxic properties. In the present study, simple cinnamic acids were synthesized by Knoevenagel condensation reactions and evaluated for the above biological activities. Compound 4ii proved to be the most potent LOX inhibitor. Phenylsubstituted acids showed better inhibitory activity against soybean LOX, and it must be noted that compounds 4i and 3i with higher lipophilicity values resulted less active than compounds 2i and 1i. The compounds have shown very good activity in different antioxidant assays. The antitumor properties of these derivatives have been assessed by their 1/IC50 inhibitory values in the proliferation of HT-29, A-549, OAW-42, MDA-MB-231, HeLa and MRC-5 normal cell lines. The compounds presented low antitumor activity considering the IC50 values attained for the cell lines, with the exception of compound 4ii. Molecular docking studies were carried out on cinnamic acid derivative 4ii and were found to be in accordance with our experimental biological results.

Synthesis, Properties, and Thermodynamic Ionization Constants of α-Phenylstyrylacrylohydroxamic Acids

The synthesis and properties of eight new hydroxamic acids derived from α-phenylstyrylacrylic acids are described. These hydroxamic acids, which are crystalline compounds, were characterized by their ultraviolet, infrared, and NMR spectra. The purity was checked by HPLC and HPTLC. The nonaqueous titrations and alkaline hydrolysis are reported. Thermodynamic ionization constants at (25 and 35 +/- 0.1) deg C are determined. Preliminary studies show that these acids form a chloroform-extractable violet complex with vanadium(V) in 6 M hydrochloric acid solutions.