1245823-50-0

Basic information

• Product Name: Propargyl-PEG5-t-butyl ester
• Synonyms: Propargyl-PEG5-t-butyl ester;Alkyne-PEG5-CH2CH2COOtBu
• CAS NO: 1245823-50-0
• Molecular Formula: C₁₈H₃₂O₇
• Molecular Weight: 360.44248
• Mol File: 1245823-50-0.mol

Chemical Properties

• Boiling Point: 420.6±40.0 °C(Predicted)
• Appearance: /
• Density: 1.045±0.06 g/cm3(Predicted)
• CAS DataBase Reference: Propargyl-PEG5-t-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Propargyl-PEG5-t-butyl ester(1245823-50-0)
• EPA Substance Registry System: Propargyl-PEG5-t-butyl ester(1245823-50-0)

Safety Data

• Hazardous Substances Data: 1245823-50-0(Hazardous Substances Data)

Usage

Uses

Used in Bioconjugation:
Propargyl-PEG5-t-butyl ester is used as a bioconjugation agent for the selective and efficient attachment of azide-bearing biomolecules through copper-catalyzed Click Chemistry. The t-butyl ester group can be removed under acidic conditions, allowing for the subsequent functionalization of the molecule.
Used in Drug Delivery Systems:
In the pharmaceutical industry, Propargyl-PEG5-t-butyl ester is used as a component in drug delivery systems to improve the solubility, stability, and bioavailability of therapeutic agents. The PEG units enhance the water solubility of the drug, while the propargyl group allows for the attachment of targeting ligands or imaging agents through Click Chemistry.
Used in Materials Science:
In materials science, Propargyl-PEG5-t-butyl ester is used as a building block for the synthesis of functional polymers and materials with tunable properties. The propargyl group can be used to incorporate various functional groups or moieties through Click Chemistry, while the PEG units provide enhanced solubility and stability.
Used in Chemical Synthesis:
Propargyl-PEG5-t-butyl ester is used as an intermediate in the synthesis of various organic compounds and pharmaceuticals. The propargyl group can be converted into other functional groups through various chemical reactions, while the PEG units provide solubility and stability to the final product.

Upstream product

• 1663-39-4 tert-Butyl acrylate 
• 96042-30-7 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran 
• 87450-10-0 3,6,9,12-tetraoxapentadec-14-yn-1-ol 

Downstream Products

• 1245823-51-1 4,7,10,13,16‐pentaoxanonadec‐18‐ynoic acid 

Relevant articles and documents

Thiodigalactoside-Bovine Serum Albumin Conjugates as High-Potency Inhibitors of Galectin-3: An Outstanding Example of Multivalent Presentation of Small Molecule Inhibitors

Galectin inhibitors are urgently needed to understand the mode of action and druggability of different galectins, but potent and selective agents still evade researchers. Small-sized inhibitors based on thiodigalactoside (TDG) have shown their potential while modifications at their C3 position indicated a strategy to improve selectivity and potency. Considering the role of galectins as glycoprotein traffic police, involved in multivalent bridging interactions, we aimed to create multivalent versions of the potent TDG inhibitors. We herein present for the first time the multivalent attachment of a TDG derivative using bovine serum albumin (BSA) as the scaffold. An efficient synthetic method is presented to obtain a novel type of neoglycosylated proteins loaded with different numbers of TDG moieties. A polyethylene glycol (PEG)-spacer is introduced between the TDG and the protein scaffold maintaining appropriate accessibility for an adequate galectin interaction. The novel conjugates were evaluated in galectin binding and inhibition studies in vitro. The conjugate with a moderate density of 19 conjugated TDGs was identified as one of the most potent multivalent Gal-3 inhibitors so far, with a clear demonstration of the benefit of a multivalent ligand presentation. The described method may facilitate the development of specific galectin inhibitors and their application in biomedical research.

"clickable", polymerized liposomes as a versatile and stable platform for rapid optimization of their peripheral compositions

A versatile and stable liposomal platform is developed for rapid optimization of its peripheral composition. The platform is based on polydiacetylene lipids terminated with alkynyl groups. Conditions for copper-catalyzed azide-alkyne cycloaddition (a "click" reaction) are optimized for rapid attachment of azides with controlled composition onto the liposomes.

NOVEL CONJUGATES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF

Provided herein are cryptophycin conjugates and compositions containing them. Methods of making and using such compounds also are provided