1246021-94-2

Basic information

• Product Name: C₆₅H₁₀₅NO₁₆Si
• Synonyms: C₆₅H₁₀₅NO₁₆Si
• CAS NO: 1246021-94-2
• Molecular Weight: 1184.63
• Mol File: 1246021-94-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₆₅H₁₀₅NO₁₆Si(CAS DataBase Reference)
• NIST Chemistry Reference: C₆₅H₁₀₅NO₁₆Si(1246021-94-2)
• EPA Substance Registry System: C₆₅H₁₀₅NO₁₆Si(1246021-94-2)

Safety Data

• Hazardous Substances Data: 1246021-94-2(Hazardous Substances Data)

Upstream product

• 179076-04-1 31-(triethylsilylether)rapamycin 
• 408322-03-2 2,2,5-trimethyl-1,3-dioxane-5-carboxylic anhydride 

Downstream Products

• 162635-04-3 temsirolimus 

Relevant articles and documents

Process for preparation of temsirolimus

The present invention provides two synthetic routes for the preparation of Temsirolimus (compound 1b and analog of Temsirolimus 1a). The first route includes the synthesis of CCI-779 by directly reacting rapamycin (4b) or Prolyl-rapamycin (4a) with substituent-2,2-bis(methoxy) propionic acid anhydride(11) in the presence of an organic base, followed by deprotection to give CCI-779 or Proline CCI-779. The second route includes a process involving a reaction of rapamycin-OH-31-sily ether (4d) or Prolyl-rapamycin-OH-31-sily ether (4c) with substituent-2,2-bis(methoxy) propionic acid anhydride(11) in the presence of an organic base and followed by subsequent hydrolysis step to obtain the desired CCI-779 or Proline CCI-779. Compound 11, as described in this invention, is stable at room temperature, cost effective and ease of processing.