1246082-03-0

Basic information

• Product Name: 6-((benzylamino)methyl)-2H-benzo[b][1,4]oxazin-3(4H)-one
• Synonyms: 6-((benzylamino)methyl)-2H-benzo[b][1,4]oxazin-3(4H)-one
• CAS NO: 1246082-03-0
• Molecular Weight: 268.315
• Mol File: 1246082-03-0.mol

Chemical Properties

• CAS DataBase Reference: 6-((benzylamino)methyl)-2H-benzo[b][1,4]oxazin-3(4H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-((benzylamino)methyl)-2H-benzo[b][1,4]oxazin-3(4H)-one(1246082-03-0)
• EPA Substance Registry System: 6-((benzylamino)methyl)-2H-benzo[b][1,4]oxazin-3(4H)-one(1246082-03-0)

Safety Data

• Hazardous Substances Data: 1246082-03-0(Hazardous Substances Data)

Upstream product

• 3011-34-5 4-hydroxy-3-nitrobenzaldehyde 
• 476313-39-0 4-methoxylcarbonylmethoxy-3-nitro-benzaldehyde 
• 100-46-9 benzylamine 
• 200195-15-9 3-oxo-3,4-dihydro-2H-benzo[1,4]oxazine-6-carbaldehyde 

Relevant articles and documents

Discovery of novel benzo[b][1,4]oxazin-3(4H)-ones as poly(ADP-ribose) polymerase inhibitors

Structure based drug design of a series of novel 1,4-benzoxazin-3-one derived PARP-1 inhibitors are described. The synthesis, enzymatic & cellular activities and pharmacodynamic effects are described. Optimized analogs demonstrated inhibition of poly-ADP-ribosylation in SW620 tumor bearing nude mice through 24 h following a single dose.

POLY (ADP-RIBOSE) POLYMERASE (PARP) INHIBITORS

Compounds of the following formula are provided for use in inhibiting Poly (ADP-ribose) Polymerase (PARP): wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds,