1246083-87-3

Basic information

• Product Name: N-methyl-4-(4-((2-methyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)methyl)piperazin-1-yl)benzamide
• Synonyms: N-methyl-4-(4-((2-methyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)methyl)piperazin-1-yl)benzamide
• CAS NO: 1246083-87-3
• Molecular Weight: 394.473
• Mol File: 1246083-87-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-methyl-4-(4-((2-methyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)methyl)piperazin-1-yl)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-methyl-4-(4-((2-methyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)methyl)piperazin-1-yl)benzamide(1246083-87-3)
• EPA Substance Registry System: N-methyl-4-(4-((2-methyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)methyl)piperazin-1-yl)benzamide(1246083-87-3)

Safety Data

• Hazardous Substances Data: 1246083-87-3(Hazardous Substances Data)

Upstream product

• 701-49-5 4-fluoro-N-methylbenzamide 
• 456-22-4 4-Fluorobenzoic acid 
• 3011-34-5 4-hydroxy-3-nitrobenzaldehyde 
• 1246081-86-6 methyl 2-(4-formyl-2-nitrophenoxy)propanoate 
• 221311-44-0 2-methyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-6-carbaldehyde 
• 1018569-94-2 N-methyl-4-(piperazin-1-yl)benzamide 

Relevant articles and documents

Discovery of novel benzo[b][1,4]oxazin-3(4H)-ones as poly(ADP-ribose) polymerase inhibitors

Structure based drug design of a series of novel 1,4-benzoxazin-3-one derived PARP-1 inhibitors are described. The synthesis, enzymatic & cellular activities and pharmacodynamic effects are described. Optimized analogs demonstrated inhibition of poly-ADP-ribosylation in SW620 tumor bearing nude mice through 24 h following a single dose.