1246084-19-4

Basic information

• Product Name: 4-(4-((2,8-dimethyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)methyl)piperazin-1-yl)-N-methylbenzamide
• CAS NO: 1246084-19-4
• Molecular Weight: 408.5
• Mol File: 1246084-19-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-(4-((2,8-dimethyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)methyl)piperazin-1-yl)-N-methylbenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-((2,8-dimethyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)methyl)piperazin-1-yl)-N-methylbenzamide(1246084-19-4)
• EPA Substance Registry System: 4-(4-((2,8-dimethyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)methyl)piperazin-1-yl)-N-methylbenzamide(1246084-19-4)

Safety Data

• Hazardous Substances Data: 1246084-19-4(Hazardous Substances Data)

Upstream product

• 701-49-5 4-fluoro-N-methylbenzamide 
• 456-22-4 4-Fluorobenzoic acid 
• 54674-91-8 4-hydroxy-3-methyl-5-nitrobenzaldehyde 
• 1246081-88-8 methyl 2-(4-formyl-2-methyl-6-nitrophenoxy)propanoate 

Relevant articles and documents

Discovery of novel benzo[b][1,4]oxazin-3(4H)-ones as poly(ADP-ribose) polymerase inhibitors

Structure based drug design of a series of novel 1,4-benzoxazin-3-one derived PARP-1 inhibitors are described. The synthesis, enzymatic & cellular activities and pharmacodynamic effects are described. Optimized analogs demonstrated inhibition of poly-ADP-ribosylation in SW620 tumor bearing nude mice through 24 h following a single dose.