124629-69-2

Upstream product

• 118789-49-4 C₃₄H₄₂O₆ 
• 124629-67-0 7(R)-benzoyloxy pentadeca-3(E),5(E)-diene-1,9-diyne 
• 97579-27-6 C₃₇H₄₆O₆ 
• 1053634-06-2 (R)-1-[(4R,5R)-5-((R)-1-Hydroxy-non-3-ynyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-non-3-yn-1-ol 
• 124629-65-8 7(R)-benzoyloxy-1-trimethylsilyl pentadeca-3(E),5(E)-diene-1,9-diyne 
• 124629-64-7 4(R)-benzoyloxy dodec-2(E)-en-6-ynal 
• 124629-63-6 2(R)-benzoyloxy-dec-4-ynal 
• 42017-07-2 1-heptynyllithium 
• 99017-09-1 ((E)-5-Trimethylsilanyl-pent-2-en-4-ynyl)-phosphonic acid dimethyl ester 
• 90108-26-2 (2R)-2-<(tert-butyldiphenylsilyl)oxy>-4-decynal 
• 124629-68-1 7(R)-hydroxy pentadeca-3(E),5(E)-diene-1,9-diyne 
• 58479-61-1 tert-butylchlorodiphenylsilane 

Downstream Products

• 140611-24-1 12(R)-(tert-butyldiphenylsilyloxy) 5(RS)-hydroxy icosa-8(E),10(E)-diene 6,14-diynoate de methyle 

Relevant academic research and scientific papers

Total Synthesis of the Ethanol Inducible, Proinflammatory Autacoid 3(S)-Hydroxy-Leukotriene B4 (3-OH-LTB4) and Analogues

3(S)-Hydroxy-Leukotriene B4 (1a), its 3(R)-epimer 1b, and 14,15-acetylenic analogue were efficiently prepared via chelation-controlled reduction of ketone 12, obtained by acetylide addition to chiral β-hydroxylactones 7/9. - Key Words: eicosanoid, chelati

Synthesis of 12-O-benzoyl 6,7,14,15-tetrahydro leucotriene B4 methyl ester, a precursor of labelled LTB4.

Leucotriene B4 (LTB4), a 5-lipoxygenase metabolite of arachidonic acid, is an important mediator of inflammatory processes and of acute hypersensitivity reactions.The availability of isotopically labelled versions of this natural metabolite is of primary

Total synthesis of 12-O-benzoyl-6,7,14,15-tetradehydro leukotriene B4 methyl ester: precursor of labeled LTB4

12-O-Benzoyl-6,7,14,15-tetrahydroleukotriene B4 methyl ester 1, the direct precursor of isotopically labeled LTB4's, has been prepared.This synthesis was accomplished by the assembly of two key chirons: α-hydroxyaldehyde of R confiur