97579-27-6Relevant articles and documents
Synthesis of 12-O-benzoyl 6,7,14,15-tetrahydro leucotriene B4 methyl ester, a precursor of labelled LTB4.
Pontikis, R,Musci, A,Merrer, Y le,Depezay, JC
, p. 968 - 975 (2007/10/02)
Leucotriene B4 (LTB4), a 5-lipoxygenase metabolite of arachidonic acid, is an important mediator of inflammatory processes and of acute hypersensitivity reactions.The availability of isotopically labelled versions of this natural metabolite is of primary
Total Synthesis of Leukotriene B44> and Homo-LTB4 from D-Mannitol
Merrer, Yves Le,Gravier-Pelletier, Christine,Micas-Languin, Dominique,Mestre, Francoise,Dureault, Annie,Depezay, Jean-Claude
, p. 2409 - 2416 (2007/10/02)
A convergent total synthesis of leukotriene B4 and its homo analogue has been carried out via enantiomerically pure α-hydroxy aldehydes, chiral key intermediates obtained from D-mannitol and connected at a four carbon atom interval by Wittig re