124629-72-7Relevant academic research and scientific papers
Synthesis of 12-O-benzoyl 6,7,14,15-tetrahydro leucotriene B4 methyl ester, a precursor of labelled LTB4.
Pontikis, R,Musci, A,Merrer, Y le,Depezay, JC
, p. 968 - 975 (2007/10/02)
Leucotriene B4 (LTB4), a 5-lipoxygenase metabolite of arachidonic acid, is an important mediator of inflammatory processes and of acute hypersensitivity reactions.The availability of isotopically labelled versions of this natural metabolite is of primary
Total synthesis of 12-O-benzoyl-6,7,14,15-tetradehydro leukotriene B4 methyl ester: precursor of labeled LTB4
Pontikis, Renee,Randrianasolo, Lalatiana R.,Merrer, Yves Le,Nam, Nguyen Hoang,Azerad, Robert,Depezay, Jean-Claude
, p. 2240 - 2242 (2007/10/02)
12-O-Benzoyl-6,7,14,15-tetrahydroleukotriene B4 methyl ester 1, the direct precursor of isotopically labeled LTB4's, has been prepared.This synthesis was accomplished by the assembly of two key chirons: α-hydroxyaldehyde of R confiur
