124643-40-9Relevant academic research and scientific papers
Copper-free palladium-catalyzed sonogashira-type coupling of aryl halides and 1-aryl-2-(trimethylsilyl)acetylenes
S?rensen, Ulrik S.,Pombo-Villar, Esteban
, p. 2697 - 2703 (2005)
A one-pot procedure for the direct coupling of 1-aryl-2- trimethylsilylacetylenes with aryl halides to give diaryl acetylenes is reported. The procedure does not involve the use of copper(I) iodide. Improvement in reaction yields has been obtained by replacing conventional oil bath heating with the use of microwave dielectric heating.
One-Pot Synthesis of N-Imidoyl-(1 H)-indoles via Palladium-Catalyzed Oxidative Insertion Domino Reaction with Isocyanide and Arylboronic Acid
Tao, Shou-Wei,Zhou, Jing-Ya,Liu, Rui-Qing,Zhu, Yong-Ming
, p. 8121 - 8130 (2019/06/24)
Efficient one-pot synthesis of N-imidoyl-(1H)-indoles has been described, which is achieved by the palladium-catalyzed oxidative insertion of 2-(phenylethynyl)aniline, arylboronic acid, and isonitrile. This method provides a new way to synthesize N-imidoy
Cobalt-Catalyzed Enantioselective Hydroboration/Cyclization of 1,7-Enynes: Asymmetric Synthesis of Chiral Quinolinones Containing Quaternary Stereogenic Centers
Wu, Caizhi,Liao, Jiayu,Ge, Shaozhong
supporting information, p. 8882 - 8886 (2019/06/13)
An asymmetric cobalt-catalyzed hydroboration/cyclization of 1,7-enynes to synthesize chiral six-membered N-heterocyclic compounds was developed. A variety of aniline-tethered 1,7-enynes react with pinacolborane to afford the corresponding chiral boryl-fun
Photoredox Decarboxylative Alkylation/(2+2+1) Cycloaddition of 1,7-Enynes: A Cascade Approach Towards Polycyclic Heterocycles Using N-(Acyloxy)phthalimides as Radical Source
Correia, José Tiago Menezes,Piva da Silva, Gustavo,André, Elias,Paix?o, Márcio Weber
supporting information, p. 5558 - 5564 (2019/09/16)
No Abstract. (Figure presented.).
Sequential hydration-condensation-double cyclization of pyridine-substituted 2-alkynylanilines: An efficient approach to quinoline-based heterocycles
Peng, Lijie,Wang, Honggen,Peng, Changlan,Ding, Ke,Zhu, Qiang
scheme or table, p. 1723 - 1732 (2011/07/09)
An environmentally benign and atom-economical process to construct a unique quinoline-based tetracyclic scaffold, through sequential hydration- condensation-double cyclization reactions, has been described. The reaction starts with readily available pyrid
Structure-activity relationships of substituted 1-pyridyl-2-phenyl-1,2- ethanediones: Potent, selective carboxylesterase inhibitors
Young, Brandon M.,Hyatt, Janice L.,Bouck, David C.,Chen, Taosheng,Hanumesh, Parimala,Price, Jeanine,Boyd, Vincent A.,Potter, Philip M.,Webb, Thomas R.
supporting information; experimental part, p. 8709 - 8715 (2011/02/23)
Inhibition of intestinal carboxylesterases may allow modification of the pharmacokinetics/pharmacodynamic profile of existing drugs by altering half-life or toxicity. Since previously identified diarylethane-1,2-dione inhibitors are decidedly hydrophobic,
One-pot/four-step/palladium-catalyzed synthesis of indole derivatives: The combination of heterogeneous and homogeneous systems
Sakai, Hayato,Tsutsumi, Ken,Morimoto, Tsumoru,Kakiuchia, Kiyomi
supporting information; experimental part, p. 2498 - 2502 (2009/08/14)
One-pot, four-step syntheses of indoles using both solid-supported heterogeneous and homogeneous palladium catalysts and reagents were carried out. Such a combination of these two-phase catalysts and reagents causes a dramatic increase in yield, and it is a simple process. The presented methodology is effective for four-step reactions to provide various functionalized indoles.
PALLADIUM-CATALYSED COUPLING OF ARYL AND VINYL TRIFLATES OR HALIDES WITH 2-ETHYNYLANILINE: AN EFFICIENT ROUTE TO FUNCTIONALIZED 2-SUBSTITUTED INDOLES
Arcadi, A.,Cacchi, S.,Marinelli, F.
, p. 2581 - 2584 (2007/10/02)
The palladium(O)-catalysed coupling of aryl and vinyl triflates or halides with the easily available 2-ethynylaniline, followed by a palladium(II)-catalysed cyclization step, provides an efficient and very versatile procedure for the synthesis of function
