1246560-46-2Relevant academic research and scientific papers
Design, synthesis, and biological evaluation of benzylamino-methanone based cholesteryl ester transfer protein inhibitors
Sheikha, Ghassan Abu,Khalaf, Reema Abu,Melhem, Areej,Albadawi, Ghadeer
experimental part, p. 5721 - 5733 (2010/12/25)
Cholesteryl ester transfer protein (CETP) is a glycoprotein involved in transporting lipoprotein particles and neutral lipids between high-density lipoprotein (HDL) and low density lipoproteins (LDL) and therefore its a proper target for treating dyslipidemia and related disorders. Guided by our previosuly-reported pharmacophore and QSAR models for CETP inhibition, we synthesized and bioassayed a series of benzylamino-methanones. The most potent illustrated 30% CETP inhibition at 10 μM.
