124658-44-2

Basic information

• Product Name: 2-Butenoic acid, 4-(4-methylphenyl)-4-oxo-, ethyl ester, (2E)-
• CAS NO: 124658-44-2
• Molecular Formula: C13H14O3
• Molecular Weight: 218.252
• Mol File: 124658-44-2.mol
• Article Data: 15

Chemical Properties

• CAS DataBase Reference: 2-Butenoic acid, 4-(4-methylphenyl)-4-oxo-, ethyl ester, (2E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Butenoic acid, 4-(4-methylphenyl)-4-oxo-, ethyl ester, (2E)-(124658-44-2)
• EPA Substance Registry System: 2-Butenoic acid, 4-(4-methylphenyl)-4-oxo-, ethyl ester, (2E)-(124658-44-2)

Safety Data

• Hazardous Substances Data: 124658-44-2(Hazardous Substances Data)

Upstream product

• 122-00-9 para-methylacetophenone 
• 619-41-0 4-(bromoacetyl)toluene 
• 617-35-6 2-oxo-propionic acid ethyl ester 
• 1777-53-3 1-(p-tolyl)-2-(triphenylphosphoranylidene)ethanone 
• 1075-47-4 4-methylphenylglyoxal 
• 1071-46-1 hydrogen ethyl malonate 
• 87-91-2 diethyl (2R,3R)-tartrate 
• 924-44-7 glyoxylic acid ethyl ester 
• 64-17-5 ethanol 
• 20972-36-5 (E)-4-oxo-4-(p-tolyl)but-2-enoic acid 
• 1099-45-2 ethyl (triphenylphosphoranylidene)acetate 
• 117937-03-8 4-hydroxy-4-p-tolyl-but-2-ynoic acid ethyl ester 
• 122-52-1 triethyl phosphite 
• 762-04-9 Diethyl phosphonate 

Downstream Products

• 1107060-56-9 1-(4-methylbenzoyl)cyclopropane-2,3-dicarboxylic acid diethyl ester 
• 1116119-09-5 C₂₁H₂₁NO₃ 
• 1185984-83-1 ethyl (R)-2-(nitromethyl)-4-oxo-4-p-tolylbutanoate 
• 1310585-11-5 C₃₀H₃₀N₂O₄ 
• 1253050-32-6 C₁₄H₁₇NO₅ 
• 1416565-66-6 (R)-ethyl 2-(4,5-dimethoxy-2-hydroxyphenyl)-4-oxo-4-p-tolylbutanoate 
• 1416565-67-7 ethyl 2-(4,5-dimethoxy-2-hydroxyphenyl)-4-oxo-4-p-tolylbutanoate 
• 1228040-52-5 ethyl 2-(2-(p-tolyl)imidazo[1,2-a]pyridin-3-yl)acetate 
• 82626-48-0 N,N,6-trimethyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine-3-acetamide 
• 82626-23-1 2-(6-Chloro-2-p-tolyl-imidazo[1,2-a]pyridin-3-yl)-N,N-dimethyl-acetamide 
• 116540-98-8 C₁₉H₂₀BrN₃O 
• 365213-69-0 [2-(4-methylphenyl)imidazo[1,2-a]pyridin-3-yl]acetic acid 
• 189005-44-5 6-methyl-2-(4-methylphenyl)-imidazo<1,2-a>pyridine-3-acetic acid 
• 116540-97-7 C₁₇H₁₅BrN₂O₂ 

Relevant articles and documents

Copper-Catalyzed N-O Cleavage of α,β-Unsaturated Ketoxime Acetates toward Structurally Diverse Pyridines

The copper-catalyzed [4 + 2] annulation of α,β-unsaturated ketoxime acetates with 1,3-dicarbonyl compounds for the synthesis of three classes of structurally diverse pyridines has been developed. This method employs 1,3-dicarbonyl compounds as C2 synthons and enables the synthesis of multifunctionalized pyridines with diverse electron-withdrawing groups in moderate to good yields. The mechanistic investigation suggests that the reactions proceed through an ionic pathway.

A robust multifunctional ligand-controlled palladium-catalyzed carbonylation reaction in water

A novel, hydrophilic and recyclable methoxypolyethylene glycol (PEG)-modulated s-triazine-based multifunctional Schiff base/N,P-ligand L9 was prepared and used in Pd-catalyzed Heck-type carbonylative coupling reactions, affording diverse chalcone derivatives and 1,4-dicarbonyl esters in good yields.

Substituted 4-oxo-crotonic acid derivatives as a new class of protein kinase B (PknB) inhibitors: synthesis and SAR study

Protein kinase B (PknB) is an essential serine/threonine protein kinase required for Mycobacterium tuberculosis (M. tb) cell division and cell-wall biosynthesis. A high throughput screen using PknB identified a (E)-4-oxo-crotonic acid inhibitor, named YH-8, which was used as a scaffold for SAR investigations. A significant improvement in enzyme affinity was achieved. The results indicated that the α,β-unsaturated ketone scaffold and “trans-” configuration are essential for the activity against PknB. And compounds with an aryl group, especially with electron-withdrawing substituents on benzene ring, exhibited four fold potency than that of YH-8.