1246736-89-9Relevant academic research and scientific papers
Titanium Salen Complexes with Appended Silver NHC Groups as Nucleophilic Carbene Reservoir for Cooperative Asymmetric Lewis Acid/NHC Catalysis
Latendorf, Katja,Mechler, Melanie,Schamne, Irina,Mack, Daniel,Frey, Wolfgang,Peters, René
, p. 4140 - 4167 (2017)
Lewis acid catalysis and nucleophilic carbene catalysis are complementary fundamental concepts to accelerate and control chemical reactions of aldehyde substrates. Their efficient merger has recently been achieved using two separate catalyst species. The
Catalytic asymmetric synthesis of trans-configured β-lactones: Cooperation of Lewis acid and ion pair catalysis
Kull, Thomas,Cabrera, Jose,Peters, Rene
supporting information; experimental part, p. 9132 - 9139 (2010/09/15)
The development of the first trans-selective catalytic asymmetric [2+2] cyclocondensation of acyl halides with aliphatic aldehydes furnishing 3,4-disubstituted β-lactones is described. This work made use of a new strategy within the context of asymmetric dual activation catalysis: it combines the concepts of Lewis acid and organic aprotic ion pair catalysis in a single catalyst system. The methodology could also be applied to aromatic aldehydes and offers broad applicability (29 examples). The utility was further demonstrated by nucleophilic ringopening reactions that provide highly enantiomerically enriched anti-aldol products.
