1246788-78-2Relevant academic research and scientific papers
Dual catalysis with copper and rhenium for trifluoromethylation of propargylic alcohols: Efficient synthesis of α-trifluoromethylated enones
Egami, Hiromichi,Ide, Takafumi,Fujita, Masashi,Tojo, Toshifumi,Hamashima, Yoshitaka,Sodeoka, Mikiko
, p. 12061 - 12065 (2014)
Trifluoromethylation of propargylic alcohols to provide (Z)-α-trifluoromethylated enones and β-unsubstituted α-trifluoromethylated enones proceeded with high yield and selectivity in the presence of CuI/Re2O7. The Z isomer was formed under kinetic control, though it is less stable than the E isomer in terms of steric repulsion.
Rapid and slow generation of 1-trifluoromethylvinyllithium: syntheses and applications of CF3-containing allylic alcohols, allylic amines, and vinyl ketones
Nadano, Ryo,Fuchibe, Kohei,Ikeda, Masahiro,Takahashi, Hiroki,Ichikawa, Junji
experimental part, p. 1875 - 1883 (2011/04/22)
1-(Trifluoromethyl)vinylation is accomplished in two protocols by the in situ generation of thermally unstable 3,3,3-trifluoroprop-1-en-2-yllithium (1):1) a rapid lithium-halogen-exchange reaction of 2-bromo-3,3,3-trifluoroprop- 1-ene (2) takes effect wit
