7291-00-1

Usage

InChI:InChI=1/C10H13NO2/c1-11(2)10(12)8-4-6-9(13-3)7-5-8/h4-7H,1-3H3

Upstream product

• 100-07-2 4-methoxy-benzoyl chloride 
• 124-40-3 dimethyl amine 
• 121-98-2 methyl 4-methoxybenzoate 
• 123-11-5 4-methoxy-benzaldehyde 
• 696-62-8 para-iodoanisole 
• 68-12-2 N,N-dimethyl-formamide 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 479486-96-9 N,N-dimethyl (trimethylsilyl)methanamide 
• 66985-48-6 2-(4-methoxyphenyl)-2-(trimethylsilyloxy)acetonitrile 
• 105-13-5 4-Methoxybenzyl alcohol 
• 98098-60-3 S-(4-methoxyphenyl) 4-methoxybenzothioate 
• 506-59-2 N,N-dimethylammonium chloride 
• 15226-74-1 dicobalt octacarbonyl 
• 100-09-4 4-methoxybenzoic acid 

Downstream Products

• 15175-54-9 N,N-dimethyl-4-methoxylbenzylamine 
• 61054-32-8 3-(4-methoxy-phenyl)-5,6-dihydro-4H-cyclopenta[c]isoxazole 
• 16616-43-6 1-(4-methoxy-phenyl)-3-phenyl-propynone 
• 72169-20-1 [(4-Methoxy-phenyl)-trichlorosilanyl-methyl]-dimethyl-amine 
• 82619-80-5 1-p-Anisoylphenothiazine 
• 86977-42-6 4-anisoyl-10,11-dihydro-5H-dibenzazepine 
• 121-98-2 methyl 4-methoxybenzoate 
• 22051-15-6 3-(4-methoxybenzoyl)indole 
• 890049-10-2 (6-chloropyridin-2-yl)(4-methoxyphenyl)methanone 
• 1255640-21-1 C₁₅H₂₁NO₂ 
• 1255640-02-8 C₁₅H₁₉NO₂ 
• 7291-01-2 N,N-dimethyl-4-nitrobenzamide 
• 15190-05-3 2-(dimethylamino)-2-(4-methoxyphenyl)acetonitrile 
• 66090-19-5 2-(4'-methoxyphenyl)-4-methylfuran 

Relevant academic research and scientific papers

One-pot synthesis of a highly disperse core-shell CuO-alginate nanocomposite and the investigation of its antibacterial and catalytic properties

In this study, sodium alginate was extracted from Sargassum algae, collected from coastal waters of Bushehr, Persian Gulf, Iran and used as a stabilizing and wrapping agent for CuO nanoparticles. The synthesized nanocomposite was characterized by some spectroscopic and microscopic techniques, such as IR, XRD, Uv-vis, BET, BJH, zeta potential, SEM, TEM, HR-TEM, and XPS. The antibacterial effects of the CuO-alginate nanocomposite against some bacteria, isolated from a burn wound, were evaluated. The results showed that this nanocomposite had better antibacterial effects than its components onPseudomonas aeruginosaATCC 27853,Staphylococcus aureusATCC 12600,Streptococcus pyogenesATCC 19615, andStaphylococcus epidermidisATCC 49461. Among these,Staphylococcus aureusATCC 12600 was the most sensitive one to this nanocomposite, with the lowest minimum inhibitory concentration (2.08 mg mL?1) observed. Moreover, the synthesized nanocomposite showed good catalytic activity in the oxidative coupling of carboxylic acids withN,N-dialkylformamides toward the synthesis of amides.

Rhoda-Electrocatalyzed Bimetallic C?H Oxygenation by Weak O-Coordination

Rhodium-electrocatalyzed arene C?H oxygenation by weakly O-coordinating amides and ketones have been established by bimetallic electrocatalysis. Likewise, diverse dihydrooxazinones were selectively accessed by the judicious choice of current, enabling twofold C?H functionalization. Detailed mechanistic studies by experiment, mass spectroscopy and cyclovoltammetric analysis provided support for an unprecedented electrooxidation-induced C?H activation by a bimetallic rhodium catalysis manifold.

Continuous Flow Acylation of (Hetero)aryllithiums with Polyfunctional N,N-Dimethylamides and Tetramethylurea in Toluene

The continuous flow reaction of various aryl or heteroaryl bromides in toluene in the presence of THF (1.0 equiv) with sec-BuLi (1.1 equiv) provided at 25 °C within 40 sec the corresponding aryllithiums which were acylated with various functionalized N,N-

Palladium-Catalyzed Aminocarbonylation of Aryl Halides with N,N-Dialkylformamide Acetals

We developed a protocol for the palladium-catalyzed aminocarbonylation of aryl halides using less-toxic formamide acetals as bench-stable aminocarbonyl sources under neutral conditions. Various aryl (including heteroaryl) halides reacted with N,N-dialkylformamide acetals in the presence of a catalytic amount of tris(dibenzylideneacetone)dipalladium(0)-chloroform adduct and xantphos to give the corresponding aromatic carboxamides at 90–140 °C without any activating agents or bases in up to quantitative chemical yield. This protocol was applied to aryl bromides, aryl iodides, and trifluoromethanesulfonic acid, as well as to relatively less-reactive aryl chlorides. A wide range of functionalities on the aromatic ring of the substrates were tolerated under the aminocarbonylation conditions. The catalytic aminocarbonylation was used to prepare the insect repellent N,N-diethyl-3-methylbenzamide as well as a synthetic intermediate of the dihydrofolate reductase inhibitor triazinate.

Visible-Light Photoredox-Catalyzed Amidation of Benzylic Alcohols

A new photocatalyzed route to amides from alcohols and amines mediated by visible light is presented. The reaction is carried out in ethyl acetate as a solvent. Ethyl acetate can be defined a green and bio-based solvent. The starting materials such as the energy source are easily available, stable, and inexpensive. The reaction has shown to be general and high yielding.

Copper-Catalyzed Radical N-Demethylation of Amides Using N-Fluorobenzenesulfonimide as an Oxidant

An unprecedented N-demethylation of N-methyl amides has been developed by use of N-fluorobenzenesulfonimide as an oxidant with the aid of a copper catalyst. The conversion of amides to carbinolamines involves successive single-electron transfer, hydrogen-atom transfer, and hydrolysis, and is accompanied by formation of N-(phenylsulfonyl)benzenesulfonamide. Carbinolamines spontaneously decompose to N-demethylated amides and formaldehyde, because of their inherent instability.

Amine-Mediated Bond Cleavage in Oxidized Lignin Models

Introducing amines/ammonia into lignin cracking will allow novel bond cleavage pathways. Herein, a method of amines/ammonia-mediated bond cleavage in oxidized lignin β-O-4 models was studied using a copper catalyst at room temperature, demonstrating the effect of the amine source on the selectivity of products. For primary and secondary aliphatic amines, lignin ketone models underwent oxidative Cα?Cβ bond cleavage and Cα?N bond formation to generate aromatic amides. For ammonia, the competition between oxygen and ammonia determined the selectivity between Cα?N and Cβ?N bond formation, generating amides and α-keto amides, respectively. For tertiary amines, the lignin models underwent oxidative Cα?Cβ bond cleavage to benzoic acids. Control experiments indicated that amines act as nucleophiles attacking at the Cα or Cβ position of the oxidized β-O-4 linkage to be cleaved. This study represents a novel example that the breakage of oxidized lignin model can be regulated by amines with a copper catalyst.

HMF and furfural: Promising platform molecules in rhodium-catalyzed carbonylation reactions for the synthesis of furfuryl esters and tertiary amides

A biomass involved rhodium-catalyzed carbonylative synthesis of furfuryl esters and tertiary amides has been developed. 5-Hydroxymethylfurfural (HMF) was used as both substrate and CO surrogate for the first time in a carbonylation reaction, and both alkyl and aryl iodides were tolerated well to afford the desired furfuryl esters in moderate to good yields. In addition, furfural was also utilized as a CO source for the synthesis of tertiary amides. A variety of tertiary amides were obtained in moderate to excellent yields with good functional groups compatibility. Notably, tertiary amines were used as the amine source through a C[sbnd]N bond cleavage pathway in the absence of additional oxidant.

Structure–Activity Relationships of 1-Benzoylazulenes at the OX1 and OX2 Orexin Receptors

We previously demonstrated the potential of di- or trisubstituted azulenes as ligands (potentiators, weak agonists, and antagonists) of the orexin receptors. In this study we investigated 27 1-benzoylazulene derivatives, uncovering seven potentiators of t

A room temperature next amine control lignin model molecular breaking method

The invention relates to a room temperature next amine control lignin model molecular breaking method. The method adopts the 1 - aryl - 2 - [...] as lignin β - O - 4 model molecule, in under the action of the copper salt and an amine, is oxidized and broken C - C/C - O key; wherein a primary and secondary aliphatic amine control into aromatic amide and a phenolic compound, inorganic ammonia control generating α - one amide and phenolic compound, tertiary amine control into aromatic acid and phenol compounds. The testing process are as follows: the 1 - aryl - 2 - [...], amine compound with a copper salt in dimethyl sulfoxide in mixed, put in the pressure container, the charge air or oxygen after the replacement is closed, at room temperature, stirring the reaction 8 - 12 is H, can occur model molecular C - C/C - O bond breaking, to obtain aromatic amide, α - one amide, aromatic acid and phenol compounds. The mild conditions, cheap catalyst and oxidizing agent, various controllable reaction product, the reaction process is simple and easy to operate.