1246847-22-2Relevant academic research and scientific papers
A simple and versatile protocol for the preparation of 1,3-functionalized heterocycles utilizing benzoylpyruvates
Nolsoee, Jens M. J.,Ertan, Anne,Svensson, Mats,Weigelt, Dirk
experimental part, p. 878 - 886 (2010/08/22)
(Chemical Equation Presented) Additional Supporting Information may be found in the online version of this article. (Chemical Equation Presented) Acid-mediated condensation between benzoylpyruvates and various dinucleophiles in alcoholic solvent furnished the heterocyclic imprint in moderate to good yield. Combining a range of symmetric as well as nonsymmetric nitrogen/nitrogen or nitrogen/carbon centered dinucleophiles resulted in excellent regioselectivity. γ-Difunctionalized fused pyrimidines, pyridazines, and pyridines were produced in this manner. The protocol was designed to obviate chromatographic purification.
