1246852-15-2Relevant academic research and scientific papers
Concise synthesis of Cannabisin G
Li, Dawei,Li, Wenling,Wang, Qian,Yang, Zhaoqi,Hou, Zijie
, p. 5095 - 5098 (2010)
Cannabisin G (1), a naturally occurring lignanamide, was synthesized in 45% overall yield starting from 3-tert-butyl ethyl ferulate (6). An oxidative coupling by potassium ferricyanide in an alkaline media serves as the key step to construct the biphenylb
Regioselective Oxidation Approaches to Concise Synthesis of (±)-Canabisin D
Li, Wenling,Liu, Qian,Liu, Hao,Chen, Peilan,Yang, Xi,Liu, Yingying
, p. 717 - 722 (2015)
The regioselective effects of tert-butyl or bromine as the position-protecting group of feruloytyamide on the oxidative coupling reactions for the synthesis of natural (±)-canabisin D were investigated in detail. The coupling yield of 8-8-coupled aryldihydronaphthalene product of 5-Br-feruloytyamide was higher than that of tert-butyl substituted precursor under FeCl3·6H2O-acetone-water oxidative condition. FeCl3·6H2O-catalyzed oxidative coupling reactions of feruloytyamide protected by tert-butyl or bromine group produced the desired 8-8-coupled aryldihydronaphthalene products, which underwent the debutylation or debromination to concisely synthesize (±)-canabisin D.
