144506-19-4

Basic information

• Product Name: Cannabisin D
• Synonyms: Cannabisin D;(1R,2S)-rel-1,2-Dihydro-7-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-N2,N3-bis[2-(4-hydroxyphenyl)ethyl]-6-methoxy-2,3-naphthalenedicarboxamide
• CAS NO: 144506-19-4
• Molecular Formula: C36H36N2O8
• Molecular Weight: 624.67964
• Mol File: 144506-19-4.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Cannabisin D(CAS DataBase Reference)
• NIST Chemistry Reference: Cannabisin D(144506-19-4)
• EPA Substance Registry System: Cannabisin D(144506-19-4)

Safety Data

• Hazardous Substances Data: 144506-19-4(Hazardous Substances Data)

Usage

Description

Cannabisin D, a chemical compound found in cannabis plants, is a dimeric form of cannabidiol (CBD) and belongs to the group of cannabinoids. It exhibits potential anti-inflammatory and anti-cancer properties, with research indicating its ability to inhibit cancer cell growth and reduce inflammation. Additionally, it possesses antioxidant properties and shows promise in treating neurodegenerative diseases. Its minimal psychotropic effects make it a potentially valuable therapeutic agent with a wide range of medical applications.

Uses

Used in Pharmaceutical Industry:
Cannabisin D is used as an anti-inflammatory agent for its ability to reduce inflammation in the body. It is also used as an anti-cancer agent for its potential to inhibit the growth of cancer cells.
Used in Neurodegenerative Disease Treatment:
Cannabisin D is used as a therapeutic agent for its promise in treating neurodegenerative diseases, such as Alzheimer's and Parkinson's, due to its antioxidant properties and potential neuroprotective effects.
Used in Cosmetic Industry:
Cannabisin D is used as an ingredient in cosmetic products for its anti-inflammatory and antioxidant properties, which can help improve skin health and reduce signs of aging.
Used in Nutraceutical Industry:
Cannabisin D is used as a dietary supplement for its potential health benefits, including anti-inflammatory, anti-oxidant, and neuroprotective effects.
Used in Drug Delivery Systems:
Cannabisin D can be incorporated into drug delivery systems to enhance its bioavailability and therapeutic outcomes, particularly in the treatment of cancer and neurodegenerative diseases.

Upstream product

• 1135-24-6 (E)-3-(4-hydroxy-3-methoxyphenyl)acrylic acid 
• 66648-43-9 (E)-N-feruloyltyramine 
• 1246852-15-2 (E)-3-(3-tert-butyl-4-hydroxy-5-methoxyphenyl)-N-(2-(4-hydroxyphenyl)ethyl)-2-propenamide 
• 6948-33-0 trans-3-(5-bromo-4-hydroxy-3-methoxyphenyl)-2-propenoic acid 
• 60-19-5 tyramine hydrochloride 

Relevant articles and documents

Regioselective Oxidation Approaches to Concise Synthesis of (±)-Canabisin D

The regioselective effects of tert-butyl or bromine as the position-protecting group of feruloytyamide on the oxidative coupling reactions for the synthesis of natural (±)-canabisin D were investigated in detail. The coupling yield of 8-8-coupled aryldihydronaphthalene product of 5-Br-feruloytyamide was higher than that of tert-butyl substituted precursor under FeCl3·6H2O-acetone-water oxidative condition. FeCl3·6H2O-catalyzed oxidative coupling reactions of feruloytyamide protected by tert-butyl or bromine group produced the desired 8-8-coupled aryldihydronaphthalene products, which underwent the debutylation or debromination to concisely synthesize (±)-canabisin D.

TERMITE ANTIFEEDANT ACTIVITY IN XYLOPIA AETHIOPICA

A heaxne extract of xylopia aethiopica fruits and an aqueous methanol extract of the seeds were studied for termite antifeedant activity against workers of the subterranean termite, Reticullitermes speratus.The crude extract, at1percent exhibited strong antifeedant activity in a choice filter paper disk bioassay.Bioassay-directed fractionation led to the isolation and identification of six ent-kaurane diterpenes in the hexane extract.Feeding deterrent activity varied significantly with the structures when the compounds were tested at concentrations ranging from 5000 ppm (40 μg cm-2) to 100 ppm (0.824 μg cm-2). (-)-Kaur-16-en-19-oic acid had the strongest termite antifeedants activity among the ent-kauranes isolated.Two phenolic amides and four lignanamides were also isolated from the aqueous methanolic extract of seeds.E-3-(4-hydroxy-3-methoxyphenyl)-N-2-2-propenamide was more active than E-3 (3,4-dihydroxyphenyl)-N-2-2-propenamide, whilst grossamide and the new lignanamide, demethylgrossamide, as well as (-)-cannabisins B and D exhibited potent feeding deterrent activity at 5000 ppm.The identity of these compounds was established by spectroscopic analysis and synthesis.Two synthetic amides, E-3-(3,4-methylenedioxyphenyl)-N-2- propenamide and E-3-(3,4-methylenedioxyphenyl)-N-2--2-propenamide were also tested for antifeedant activity. - Keywords: xylopia aethiopica; Annonaceae; seeds; fruits; Reticullitermes speratus; Isoptera; antifeedants; ent-kaurane diterpenes; phenolic amides; lignanamides.