1247-70-7

Usage

Synthetic form

16B-Hydroxyestrone diacetate is a synthetic form of the hormone 16B-hydroxyestrone, which is produced in the body from the metabolism of estrogen.

Estrogenic compound

It is an estrogenic compound, meaning it has similar effects to the hormone estrogen.

Research and medical studies

It is often used in research and medical studies to investigate its effects on the body.

Potential role in breast cancer

It has been studied for its potential role in breast cancer and other hormone-related diseases.

Involvement in bone metabolism

It has been studied for its involvement in bone metabolism.

Reproductive health

It has been studied for its effects on reproductive health.

Better stability

The diacetate form of 16B-hydroxyestrone allows for better stability in research settings.

Controlled release

The diacetate form allows for controlled release, making it a valuable tool for studying the role of estrogen in various physiological processes.

Upstream product

• 20592-42-1 estra-1,3,5⁽¹⁰⁾,16-tetraene-3,17-diol diacetate 
• 108-24-7 acetic anhydride 
• 966-06-3 16beta-Hydroxyestrone 

Downstream Products

• 966-06-3 16beta-Hydroxyestrone 
• 547-81-9 epiestriol 

Relevant academic research and scientific papers

Production of 16β-(acetoxy)acetoxy derivatives by reaction of 17-keto steroid enol acetates with lead (IV) acetate

Treatment of enol acetates of 3β-acetoxyandrost-5-en-17-one and its 5α-reduced analog, 5α-androstan-17-one, and estrone acetate, 1-4, with Pb(OCOCH3)4 in acetic acid and acetic anhydride gave the previously unreported products, 16β-(acetoxy)acetoxy-17-ketones 8-10 and 12, in 9-15% yields along with the known major products, 16β-acetoxy-17-ketones 5-7 and 11. Similar treatment of the 16β-acetoxy-17-ketones with the lead reagent did not yield the corresponding (acetoxy)acetates. Reaction of the enol acetate 3 with Pb(OCOCD3)4 in CD3COOD yielded principally the labeled (acetoxy)acetate 10-d3, which had a CD3COOCH2COO moiety at C-16β. In contrast, when the deuterated enol acetate 3-d3, which was obtained by treatment of the 17-ketone 14 with (CD3CO)2O in the presence of LDA and which had a CD3COO moiety at C-17, was reacted with Pb(OCOCH3)4, the resulting product was the labeled compound 10-d2. This product had a CH3COOCD2COO function at C-16β. Based on these results, along with further isotope-labeling experiments, it seems likely that the (acetoxy)acetate is produced through a lead (IV) acetate-catalyzed migration of the 17-acetyl function of the enol acetate to the C-16β-position followed by attack of an acetoxy anion of the lead reagent. Copyright

Novel 17-amino-16-hydroxy steroids of the androstane and oestrane series and derivatives thereof

New and pharmacologically useful 17-amino-16-hydroxy-steroids of the androstane and oestrane series are disclosed having the formula I: STR1 and pharmaceutically acceptable non-toxic acid addition salts thereof, wherein: R1 =H or hydrocarbyl of one to six carbon atoms (preferably lower alkyl, such as methyl); R2 =H or hydrocarbyl of one to six carbon atoms (preferably lower alkyl, such as methyl); R3 =a free, esterified or etherified hydroxyl group; ring A inclusive carbon atoms 6 and 9 has one of the following configurations: STR2 in which R4 =a free, esterified or etherified hydroxyl group; R5 =O or H(R7), wherein R7 is a free, esterified or etherified hydroxyl group; R6 =H or methyl; and the dotted lines represent an optional double bond in 4,5- or 5,6-position; as well as the enantiomers and racemates of these steroids. The novel compounds have antiarrhythmic properties.