124700-70-5

Basic information

• Product Name: 4-Pyrimidinol, 2-(methylthio)- (9CI)
• Synonyms: 4-Pyrimidinol, 2-(methylthio)- (9CI)
• CAS NO: 124700-70-5
• Molecular Formula: C5H6N2OS
• Molecular Weight: 142.18
• Mol File: 124700-70-5.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 301.2 °C at 760 mmHg
• Flash Point: 136 °C
• Appearance: /
• Density: 1.35 g/cm³
• PKA: 7.18±0.20(Predicted)
• CAS DataBase Reference: 4-Pyrimidinol, 2-(methylthio)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Pyrimidinol, 2-(methylthio)- (9CI)(124700-70-5)
• EPA Substance Registry System: 4-Pyrimidinol, 2-(methylthio)- (9CI)(124700-70-5)

Safety Data

• Hazardous Substances Data: 124700-70-5(Hazardous Substances Data)

Usage

General Description

4-Pyrimidinol, 2-(methylthio)-(9CI) is a chemical compound with the molecular formula C5H6N2OS. It is a derivative of pyrimidine and contains a sulfur atom attached to a methyl group at the 2-position of the pyrimidinol ring. 4-Pyrimidinol, 2-(methylthio)- (9CI) is used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. It has potential applications in the development of new drugs and chemical products due to its unique structure and reactivity. Further research is necessary to explore its properties and potential uses in various industries.

Upstream product

• 5751-20-2 2-Methylthiouracil 
• 141-90-2 2-thiouracil 
• 77-78-1 dimethyl sulfate 
• 141-90-2 4-hydroxy-2-mercaptopyrimidine 
• 74-88-4 methyl iodide 

Downstream Products

• 189956-45-4 4-[(4-hydroxy-2-pyrimidinyl)amino]benzonitrile 
• 456-64-4 phenyl trifluoromethanesulfonamide 
• 154499-77-1 2-methylthio-4-pyrimidinyl triflate 

Relevant articles and documents

Synthesis method of 4-chloro-2-methylthiopyrimidine

The invention belongs to the technical field of organic synthesis, in particular to a synthesis method of 4-chloro-2-methylthiopyrimidine. The method includes taking 2-thiouracil as a raw material, dimethyl sulfate as a methylation reagent, thionyl chloride and phosphorus oxychloride as a chlorination reagent, and synthesizing the 4-chloro-2-methylthiopyrimidine through methylation and chlorination.The dimethyl sulfate is taken as the methylation reagent to replace methyl bromide or methyl iodide, and thus the safety of the reaction is increased, and the cost is decreased; sodium hydroxide istaken as alkali to replace sodium methoxide or butyl lithium, and thus the safety of the reaction is increased, and the cost is reduced; toluene is taken as a reaction solvent, and thus the dosage ofthe chlorinated reagent is greatly reduced, the reaction safety is greatly improved, the cost is reduced, and the post-treatment operation is simplified; and the sulfoxide chloride and the phosphorusoxychloride are taken as the mixed chlorinating reagent, and thus the reaction yield is greatly improved.

HETEROCYCLYL PYRIMIDINE ANALOGUES AS TYK2 INHIBITORS

The present invention relates to compounds of formula (I), wherein R, R1, X1 to X5 have the meaning as cited in the description and the claims. Said compounds are useful as TYK2 inhibitors for the treatment or prophylaxis

2-ANILINO-4-HETEROARYL PYRIMIDINE DERIVATIVES, AND PREPARATION THEREOF AS MEDICAMENTS, PHARMACEUTICAL COMPOSITIONS, AND IN PARTICULAR IKK INHIBITORS

The disclosure relates to a compound of formula (I): wherein R, R2, R3, R4, R5, z, D and W are as defined in the specification, to compositions containing them, to processes for preparing them, and to their use in the treatment or prevention of conditions capable of being modulated by the inhibition of the activity of protein kinases.