1247090-75-0Relevant academic research and scientific papers
3,4-Diarylpiperidines as potent renin inhibitors
Lacombe, Patrick,Arbour, Mélissa,Aspiotis, Renée,Cauchon, Elizabeth,Chen, Austin,Dubé, Daniel,Falgueyret, Jean-Pierre,Fournier, Pierre-André,Gallant, Michel,Grimm, Erich,Han, Yongxin,Juteau, Hélne,Liu, Suzanna,Mellon, Christophe,Ramtohul, Yeeman,Simard, Daniel,St-Jacques, René,Tsui, Gavin Chit
scheme or table, p. 1953 - 1957 (2012/04/04)
The discovery and SAR of a series of potent renin inhibitors possessing a novel 3,4-diarylpiperidine scaffold are described herein. The resulting compound 38 exhibit low nanomolar plasma renin IC50, had a clean CYP 3A4 profile and displayed mic
