1247127-79-2Relevant academic research and scientific papers
Pradefovir: A prodrug that targets adefovir to the liver for the treatment of hepatitis B
Reddy, K. Raja,Matelich, Michael C.,Ugarkar, Bheemarao G.,Gómez-Galeno, Jorge E.,DaRe, Jay,Ollis, Kristin,Sun, Zhili,Craigo, William,Colby, Timothy J.,Fujitaki, James M.,Boyer, Serge H.,Van Poelje, Paul D.,Erion, Mark D.
, p. 666 - 676 (2008/09/19)
Adefovir dipivoxil, a marketed drug for the treatment of hepatitis B, is dosed at submaximally efficacious doses because of renal toxicity. In an effort to improve the therapeutic index of adefovir, 1-aryl-1,3-propanyl prodrugs were synthesized with the r
