124782-06-5

Basic information

• Product Name: (2R,3R)-3-(N-(benzyloxycarbonyl)amino)-2-hydroxy-4-phenylbutanoic acid methyl ester
• Synonyms: (2R,3R)-3-(N-(benzyloxycarbonyl)amino)-2-hydroxy-4-phenylbutanoic acid methyl ester
• CAS NO: 124782-06-5
• Molecular Weight: 343.379
• Mol File: 124782-06-5.mol

Chemical Properties

• CAS DataBase Reference: (2R,3R)-3-(N-(benzyloxycarbonyl)amino)-2-hydroxy-4-phenylbutanoic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,3R)-3-(N-(benzyloxycarbonyl)amino)-2-hydroxy-4-phenylbutanoic acid methyl ester(124782-06-5)
• EPA Substance Registry System: (2R,3R)-3-(N-(benzyloxycarbonyl)amino)-2-hydroxy-4-phenylbutanoic acid methyl ester(124782-06-5)

Safety Data

• Hazardous Substances Data: 124782-06-5(Hazardous Substances Data)

Upstream product

• 63219-70-5 N-(benzyloxycarbonyl)-D-phenylalaninal 
• 247178-58-1 (R)-((4S,5R)-2-Benzyloxy-5-phenyl-4,5-dihydro-oxazol-4-yl)-hydroxy-acetic acid methyl ester 
• 247178-57-0 methyl (4S,5R)-2-benzyloxy-5-phenyloxazoline-4-acetate 
• 178897-35-3 (4S,5R)-4-methoxycarbonylmethyl-5-phenyloxazolidin-2-one 
• 501-53-1 benzyl chloroformate 

Downstream Products

• 144676-38-0 Aminodeoxybestatin 
• 144676-52-8 (2S,3R)-2-Azido-3-(benzyloxycarbonylamino)-4-phenylbutanoic Acid Methyl Ester 
• 144676-54-0 (2S,3R)-2-Azido-3-(benzyloxycarbonylamino)-4-phenylbutanoic Acid 
• 65391-42-6 Bestatin hydrochloride 
• 60016-66-2 benzyl N-[(2S,3R)-3-(N-benzyloxycarbonyl)amino-2-hydroxy-4-phenylbutanoyl]-L-leucinate 
• 59969-65-2 (2S,3R)-3-benzyloxycarbonylamino-2-hydroxy-4-phenyl-butanoic acid 
• 247178-59-2 methyl (2S,3R)-3-(benzyloxycarbonyl)amino-2-formyloxy-4-phenylbutanoate 
• 144676-51-7 (2R,3R)-3-(Benzyloxycarbonylamino)-2-methylsulfonyloxy-4-phenylbutanoic Acid Methyl Ester 
• 62023-58-9 (2R,3R)-3-(N-(benzyloxycarbonyl)amino)-2-hydroxy-4-phenylbutanoic acid 
• 124820-68-4 (4R,5R)-4-benzyl-2-oxo-5-oxazolidinecarboxylic acid 

Relevant articles and documents

Synthesis of methyl 3-amino-2-hydroxy-4-phenylbutanoates, important core intermediates for peptide mimics possessing biological activities

Core intermediates for the synthesis of anti-cancer agents, inhibitors of aminopeptidases and HIV proteases, 3-amino-2-hydroxy-4-phenylbutanoates were synthesized by using H-C(CN)2O-SiR3 as a key reagent.

Novel synthesis of (-)-bestatin from L-aspartic acid

Oxazoline-4-acetate derivative 3 that could be readily obtained from L-aspartic acid was subjected to highly stereoselective hydroxylation, and subsequent Mitsunobu inversion of the hydroxyl group led to (2S,3R)-3-amino-3-benzyl-2-hydroxybutanoic acid der