59969-65-2

Basic information

• Product Name: Z-(2R,3S)-AHPA
• Synonyms: (2R,3S)-3-(((benzyloxy)carbonyl)aMino)-2-hydroxy-4-phenylbutanoic acid;Z-(2R,3S)-AHPA;Z-(2S,3R)-AHPA;(alphaS,betaR)-alpha-Hydroxy-beta-[[(phenylmethoxy)carbonyl]amino]benzenebutanoic acid;2S,3R)-3-(((benzyloxy)carbonyl)-Amino)-2-hydroxy-4-phenylbutyric acid
• CAS NO: 59969-65-2
• Molecular Formula: C₁₈H₁₉NO₅
• Molecular Weight: 329.34716
• EINECS: -0
• Mol File: 59969-65-2.mol
• Article Data: 9

Chemical Properties

• Melting Point: 152-153 °C
• Boiling Point: 581.9±50.0 °C(Predicted)
• Appearance: /
• Density: 1.295±0.06 g/cm3 (20 oC 760 Torr), Calc.*
• Storage Temp.: 2-8°C
• PKA: 3.56±0.17(Predicted)
• CAS DataBase Reference: Z-(2R,3S)-AHPA(CAS DataBase Reference)
• NIST Chemistry Reference: Z-(2R,3S)-AHPA(59969-65-2)
• EPA Substance Registry System: Z-(2R,3S)-AHPA(59969-65-2)

Safety Data

• Hazardous Substances Data: 59969-65-2(Hazardous Substances Data)

Usage

General Description

The chemical Z-(2R,3S)-AHPA, also known as Z-(2S,3R)-amino-2-hydroxy-3-methylpentanoic acid, is a structural isomer of L-threo-3-hydroxyaspartate. It is an amino acid derivative containing a hydroxy- and a methyl- group attached to the alpha carbon. Z-(2R,3S)-AHPA has been found to be a potent antagonist of the glutamate receptor, particularly the kainate subtype. It has been studied for its potential to inhibit glutamate receptor-mediated neurotoxicity and its role in neurological disorders such as stroke and epilepsy. Additionally, Z-(2R,3S)-AHPA has drawn interest for its potential to modulate neurotransmission and synaptic plasticity in the brain.

Upstream product

• 59554-14-2 (2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid 
• 144676-39-1 ((R)-1-Benzyl-2-cyano-2-trimethylsilanyloxy-ethyl)-carbamic acid benzyl ester 
• 63219-70-5 N-(benzyloxycarbonyl)-D-phenylalaninal 
• 95832-35-2 (4R,5S)-3,4-Dibenzyl-5-iodomethyl-oxazolidin-2-one 
• 95832-34-1 Benzyl-((R)-1-benzyl-allyl)-carbamic acid benzyl ester 
• 95832-31-8 Z-D-phenylalanine ethyl ester 
• 95891-28-4 (4R,5S)-3,4-Dibenzyl-5-hydroxymethyl-oxazolidin-2-one 
• 95832-30-7 N-<(benzyloxy)carbonyl>-(2R)-amino-1-phenylbut-3-ene 
• 95832-38-5 methyl (4R,5S)-2-oxo-4-phenylmethyl-1,3-oxazolidine-5-carboxylate 
• 95832-37-4 (4R,5S)-5-benzyl-4-(hydroxymethyl)-1,3-oxazolidin-2-one 
• 23402-69-9 lithium diphenylcuprate 
• 152897-52-4 (S)-5-<(S)-2-phenyl-1-(N-tosylamino)ethyl>-1,3-dioxolane 
• 95105-20-7 (2S,3R)-3-amino-4-phenylbutane-1,2-diol 
• 591-51-5 phenyllithium 

Downstream Products

• 60016-66-2 benzyl N-[(2S,3R)-3-(N-benzyloxycarbonyl)amino-2-hydroxy-4-phenylbutanoyl]-L-leucinate 
• 62058-27-9 Z-(2S,3R)-AHPA-(R)-Leu-OBzl 
• 65391-42-6 Bestatin hydrochloride 
• 58970-76-6 bestatin 

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