1247847-27-3

Upstream product

• 1247847-56-8 pentachlorophenyl (2E)-3-[4-[[bis[(2,2-dimethyl-1-oxopropoxy)methoxy]phosphinyl]difluoromethyl]-phenyl]but-2-enoate 
• 1304101-69-6 TFA*H-Haic-NHCH(CH₃)CH₂CH₂CONH₂ 
• 1304101-68-5 H-Haic-NHCH(CH₃)CH₂CH₂CONH 
• 1247847-59-1 4-nitrophenyl (2E)-3-[4-[(bis[[(2,2-dimethylpropanoyl)oxy]methoxy]phosphoryl)difluoromethyl]phenyl]but-2-enoate 
• 13329-40-3 4-Iodoacetophenone 
• 1247847-54-6 (E)-3-(4-((diethoxyphosphoryl)-difluoromethyl)phenyl)but-2-enoic acid 
• 1247847-58-0 4-nitrophenyl (2E)-3-[4-(phosphoryldifluoromethyl)phenyl]but-2-enoate 
• 1247847-55-7 pentachlorophenyl (2E)-3-[4-(Phosphoryldifluoromethyl)phenyl]but-2-enoate 
• 1247847-57-9 4-nitrophenyl (2E)-3-[4-[(diethoxyphosphinyl)difluoromethyl]phenyl]but-2-enoate 
• 1247847-53-5 pentachlorophenyl (2E)-3-[4-[(diethoxyphosphinyl)difluoromethyl]phenyl]but-2-enoate 
• 1247847-52-4 tert-butyl (2E)-3-[4-[(diethoxyphosphinyl)difluoromethyl]phenyl]but-2-enoate 
• 1247847-51-3 tert-butyl (E)-3-(4-iodophenyl)but-2-enoate 
• 1189357-66-1 (R)-4-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-2-pentanoic acid 

Relevant academic research and scientific papers

Potent and selective phosphopeptide mimetic prodrugs targeted to the Src homology 2 (SH2) domain of signal transducer and activator of transcription 3

Signal transducer and activator of transcription 3 (Stat3), a target for anticancer drug design, is activated by recruitment to phosphotyrosine residues on growth factor and cytokine receptors via its SH2 domain. We report here structure-activity relation

INHIBITORS OF STAT3 AND USES THEREOF

Compounds which inhibit the activity of signal transducer and activator of transcription 3 (STAT3) are provided together with methods of making and using the same. The compounds are designed to bind to the SH2 domain of STAT3, preventing STAT3 from bindin