124887-12-3

Upstream product

• 89329-05-5 1-methyl hydrogen (3S,2R,4S)-3-hydroxy-2,4-dimethylglutarate 
• 105365-06-8 methyl 3,5-dihydoxy-2,4-dimethylpentanoate 
• 58479-61-1 tert-butylchlorodiphenylsilane 

Downstream Products

• 124887-13-4 (2S,3R,4R)-5-(tert-butyldiphenylsiloxy)-2,4-dimethylpentane-1,3-diol 
• 135681-55-9 2',6'-dimethylphenyl (2R,3R,4R,5R,6S)-3-hydroxy-5,7-isopropylidenedioxy-2,4,6-trimethylheptanonate 
• 124887-14-5 (2R,3R,4S)-1-(tert-butyldiphenylsiloxy)-3,5-isopropylidenedioxy-2,4-dimethylpentane 

Relevant academic research and scientific papers

Stereoselective synthesis of a building block corresponding to the C(1)-to-C(7) moiety of 14-membered macrolide antibiotics

The synthesis of 2',6'-dimethylphenyl (2R,3R,4R,5R,6S)-3-hydroxy-5,7-isopropylidenedioxy-2,4,6-trimethylhepta noate (13) a synthon for the C(1)-to-C(7) segment of a number of 14-membered macrolide antibiotics is described, starting from the meso-diester 3

SYNTHESIS OF A VERSATILE CHIRAL SYNTHON CORRESPONDING TO THE C(1) to C(7) SEGMENT OF 14-MEMBERED MACROLIDE ANTIBIOTICS

The synthesis of the C(1) to C(7) segment of a number of 14-membered macrolide antibiotics is described, starting from dimethyl 3-hydroxy-2,4-dimethylglutarate.