124932-43-0 Usage
Description
(R)-3-Amino-Hexahydro-1H-Azepin is an organic compound characterized by its hexahydroazepine ring structure with an amino group at the 3-position. It is a chiral molecule, with the (R)-configuration indicating the specific arrangement of the atoms in the molecule. (R)-3-Amino-Hexahydro-1H-Azepin serves as a crucial intermediate in the synthesis of various pharmaceutical compounds due to its unique structural features and reactivity.
Uses
Used in Pharmaceutical Industry:
(R)-3-Amino-Hexahydro-1H-Azepin is used as a key intermediate for the synthesis of ureido thiophene carboxamides, which are known as checkpoint kinase inhibitors. These inhibitors play a significant role in the development of cancer therapeutics, as they target specific proteins involved in cell cycle regulation and DNA damage response, thereby preventing the uncontrolled proliferation of cancer cells.
Additionally, (R)-3-Amino-Hexahydro-1H-Azepin is identified as an impurity in Besifloxacin (B319000, HCl salt), a fluoroquinolone antibiotic. Besifloxacin is used to treat bacterial infections, particularly those caused by gram-negative and gram-positive bacteria. The presence of this compound as an impurity highlights the importance of its synthesis and purification for the production of high-quality antibiotics.
Check Digit Verification of cas no
The CAS Registry Mumber 124932-43-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,4,9,3 and 2 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 124932-43:
(8*1)+(7*2)+(6*4)+(5*9)+(4*3)+(3*2)+(2*4)+(1*3)=120
120 % 10 = 0
So 124932-43-0 is a valid CAS Registry Number.
124932-43-0Relevant articles and documents
Method for preparing beixifloxacin intermediate compound
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, (2018/03/01)
The invention provides a method for preparing a beixifloxacin intermediate compound VI. The method comprises the steps of: reacting a compound of a formula III with an upper protective group, an aminotransferase catalying and a deprotecting group to obtain a compound shown in a formula VI. The method can be used for preparing the beixifloxacin intermediate compound VI rapidly and effectively. Rawmaterials are simple and easy to obtain, the reaction is simple and easy to operate, harsh reaction conditions are not required, a production period is short, yield of a target product is high, separation and purification of the target product are simple, optical purity is high, the method is easy to achieve mass production.
Novel chiral derivatizing agents for 1H NMR determination of enantiomeric purities of carboxylic acids
Wada, Koji,Goto, Mizuko,Yamashita, Hiroshi,Nagasawa, Kazuo
, p. 964 - 978 (2017/06/13)
(S)-4-(3-Aminopyrrolidin-1-yl)coumarin (1), (S)-4-(3-aminopiperidin-1-yl)coumarin (4), and (S)-4-(3-aminoazepan-1-yl)coumarin (7), prepared from 4-chlorocoumarin and (S)-pyrrolidin-3-amine, (S)-piperidin-3-amine, and (S)-azepan-3-amine, respectively, were proven to be versatile and reliable 1H NMR optical purity determination agents for chiral carboxylic acids.
COMPOUNDS AND COMPOSITIONS FOR MODULATING EGFR ACTIVITY
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Page/Page column 77, (2014/01/08)
The invention provides compounds and pharmaceutical compositions thereof, which are useful for modulating EGFR activity, as well as methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated EGFR activity.
