1354351-56-6

Basic information

• Product Name: CarbaMic acid, N-[(3R)-hexahydro-1H-azepin-3-yl]-, 1,1-diMethylethyl ester
• Synonyms: CarbaMic acid, N-[(3R)-hexahydro-1H-azepin-3-yl]-, 1,1-diMethylethyl ester;(R)-3-Boc-amino-azepane;N-[(3R)-Hexahydro-1H-azepin-3-yl]carbamic acid 1,1-dimethylethyl ester
• CAS NO: 1354351-56-6
• Molecular Formula: C11H22N2O2
• Molecular Weight: 214.30458
• Mol File: 1354351-56-6.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 322.7±31.0 °C(Predicted)
• Appearance: /
• Density: 1.01±0.1 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 12.37±0.20(Predicted)
• CAS DataBase Reference: CarbaMic acid, N-[(3R)-hexahydro-1H-azepin-3-yl]-, 1,1-diMethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: CarbaMic acid, N-[(3R)-hexahydro-1H-azepin-3-yl]-, 1,1-diMethylethyl ester(1354351-56-6)
• EPA Substance Registry System: CarbaMic acid, N-[(3R)-hexahydro-1H-azepin-3-yl]-, 1,1-diMethylethyl ester(1354351-56-6)

Safety Data

• Hazardous Substances Data: 1354351-56-6(Hazardous Substances Data)

Usage

General Description

Carbamic acid, N-[(3R)-hexahydro-1H-azepin-3-yl]-, 1,1-dimethylethyl ester is a compound commonly known as t-Boc-L-homoserine. It is a chemical compound used in the synthesis of various pharmaceuticals and organic compounds. The t-Boc group in the molecule serves as a protective group for the amine functional group, allowing for selective reactions to occur at other sites on the molecule. It is commonly used in peptide synthesis and as a building block for the production of various drugs and organic compounds. Its chemical structure and properties make it a versatile and useful compound in the field of organic chemistry and pharmaceutical research.

Upstream product

• 106691-72-9 3(R)--2-oxoperhydroazepine 
• 28957-33-7 (R)-3-amino-azepan-2-one 
• 24424-99-5 di-tert-butyl dicarbonate 
• 7274-88-6 D-lysine hydrochloride 
• 454451-26-4 3-tert-butyloxycarbonylamino-1H-azacycloheptane 
• 860354-53-6 benzyl (3S)-3-[(tert-butoxycarbonyl)amino]azepane-1-carboxylate 
• 615258-01-0 dimethyl (S)-2-[(tert-butoxycarbonyl)amino]hexanedioate 
• 213176-18-2 tert-butyl [(1S)-5-hydroxy-1-(hydroxymethyl)pentyl]carbamate 
• 157701-42-3 (S)-dimethyl 2-aminohexanedioate hydrochloride 
• 1118-90-7 L-homoglutamic acid 
• 1026172-68-8 Methanesulfonic acid (S)-2-tert-butoxycarbonylamino-6-methanesulfonyloxy-hexyl ester 

Downstream Products

• 1314944-02-9 2-[[7-(3-aminohomopiperidin-1-yl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b] pyridin-1-yl]methyl]benzonitrile trifluoroacetate 
• 1314946-17-2 1-[1-(2-cyanobenzyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-7-yl]-homopiperidin-3-yl tert-butyl carbamate 

Relevant articles and documents

Convenient synthesis of (R)-3-[(tert -Butoxycarbonyl)amino]piperidine and (R)-3-[(tert -Butoxycarbonyl)amino]azepane

(R)-3-[(tert -Butoxycarbonyl)amino]piperidine and (R)-3-[(tert -butoxycarbonyl)amino]azepane were prepared in two steps starting from d -ornithine and d -lysine, respectively. In the key step, N -Boc-protected 3-aminolactams were converted into imido esters by O-alkylation and then hydrogenated to amines, under mild conditions (5 bar H 2, room temperature) and without isolation, over a standard hydrogenation catalyst (5% Pt/C).

STEREOSELECTIVE SYNTHESIS OF PIPERIDINE DERIVATIVES

This invention relates to dialdehyde or dinitrile compounds, which are useful for stereoselective synthesis of piperidine, pyrrolidine, and azepane derivatives.

An efficient conversion of chiral α-amino acids to enantiomerically pure 3-amino cyclic amines

Enantiomerically pure 3-amino cyclic amines such as 3-amino pyrrolidine, 3-amino piperidine, and 2,3,4,5,6,7-hexahydro-1H-azepine have been synthesized in high yields from the optically active natural α-amino acids such as L-aspartic acid, L-glutamic acid, L-2-aminoadipic acid, and their enantiomers.