124937-73-1

Basic information

• Product Name: 3-(2-Methoxy-5-methylphenyl)-3-phenyl propanol
• Synonyms: 3-(2-METHOXY-5-METHYLPHENYL)-3-PHENYLPROPANOL (50% TOLUNE solution);3-(2-Methoxy-5-Methylphenyl)-3-Phenyl-1-Propanol;3-(2-Methoxy-5-methylphenyl)-3-Phenyl-1-Propanol(forTolterodine);3-(2-METHOXY-5-METHYLPHENYL)-3-PHENYL PROPANOL (FOR TOLTERODINE);3-(2-Methoxy-5-methylphenyl)-3-phenyl propanol;3-(2-METHOXY-5-METHYLPHENYL)-3-PHENYL-1-PROPANOL (FOR TOLTERODINE),99.0%;3-(-2Methoxy-5-methyl-phenyl)-3-phenyl-propan-1-ol;BENZENEPROPANOL2-METHOXY-5-METHYL-Y-PHENYL
• CAS NO: 124937-73-1
• Molecular Formula: C₁₇H₂₀O₂
• Molecular Weight: 256.34
• Product Categories: Medicine intermediate;(intermediate of tolterodine
• Mol File: 124937-73-1.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 413.8 °C at 760 mmHg
• Flash Point: 184.2 °C
• Appearance: /
• Density: 1.066 g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 14.94±0.10(Predicted)
• CAS DataBase Reference: 3-(2-Methoxy-5-methylphenyl)-3-phenyl propanol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-Methoxy-5-methylphenyl)-3-phenyl propanol(124937-73-1)
• EPA Substance Registry System: 3-(2-Methoxy-5-methylphenyl)-3-phenyl propanol(124937-73-1)

Safety Data

• Hazardous Substances Data: 124937-73-1(Hazardous Substances Data)

Usage

Uses

2-Methoxy-5-methyl-γ-phenylbenzenepropanol is a related compound to Tolterodine (T535795), a muscarinic receptor antagonist. Used in the treatment of urinary incontinence.

InChI:InChI=1/C22H31NO.ClH/c1-16(2)23(17(3)4)14-13-20(19-9-7-6-8-10-19)21-15-18(5)11-12-22(21)24;/h6-12,15-17,20,24H,13-14H2,1-5H3;1H/t20-;/m1./s1

Upstream product

• 50-00-0 formaldehyd 
• 389068-20-6 1-methoxy-4-methyl-2-(1-phenyl-vinyl)-benzene 
• 7083-19-4 2-methoxy-5-methylbenzaldehyde 
• 40546-94-9 6-methyl-4-phenyl-3,4-dihydrocoumarin 
• 109089-77-2 3-(2-methoxy-5-methyl-phenyl)-3-phenyl-propionic acid 
• 75-21-8 oxirane 

Downstream Products

• 124936-74-9 N,N-diiso-propyl-3-(2-hydroxy-5-methylphenyl)-3-phenylpropanamine 
• 1161940-88-0 N,N-diisopropyl-3-(2-methoxy-5-methylphenyl)-3-phenylpropan-1-amine hydrochloride 
• 1043911-42-7 N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenyl-propylamine L-tartrate 
• 882878-66-2 3-(2-methoxy-5-methylphenyl)-3-phenylpropyl-methanesulfonate 
• 124937-85-5 toluene-4-sulfonic acid-3-(2-methoxy-5-methyl-phenyl)-3-phenyl propyl ester 

Relevant articles and documents

Iron-catalyzed regioselective transfer hydrogenative couplings of unactivated aldehydes with simple alkenes

An FeBr3-catalyzed reductive coupling of various aldehydes with alkenes that proceeds through a direct hydride transfer pathway has been developed. With iPrOH as the hydrogen donor under mild conditions, previously challenging coupling reactions of unactivated alkyl and aryl aldehydes with simple alkenes, such as styrene derivatives and α-olefins, proceeded smoothly to furnish a diverse range of functionalized alcohols with complete linear regioselectivity. The reductive coupling of various aldehydes and alkenes through a direct hydride transfer pathway can be catalyzed by FeBr3. With isopropanol as the hydrogen donor, previously challenging coupling reactions of unactivated alkyl and aryl aldehydes with simple alkenes, such as styrene derivatives and α-olefins, proceeded smoothly to furnish a diverse range of functionalized alcohols with complete linear regioselectivity.

PROCESS FOR THE PREPARATION OF (R)-2-(3-DIISOPROPYLAMINO)-1-PHENYLPROPYL)-4METHYLPHENOL AND SALTS THEREOF

The present invention relates to an improved process for the preparation of Tolterodine or salts thereof, which comprises the use of 3-(2-methoxy-5-methylphenyl)-3-phenylpropyl methane sulfonate.

A PROCESS FOR THE PREPARATION OF TOLTERODINE TARTRATE

The present invention relates to provide a process for the preparation of (+)-(R)-Tolterodine-L-tartrate, comprises a step of aminating hydroxyl protected 3-(2-methoxy-5-methylphenyl)-3-phenyl propanol of formula (V) with diisopropylamine in the presence of water to obtain N, N-diisopropyl-3-(2-methoxy-5-methylphenyl)-3-phenylpropyl amine of formula (VI).