109089-77-2

Basic information

• Product Name: 3-(2-Methoxy-5-methylphenyl)-3-phenylpropanoic acid
• Synonyms: 3-(2-METHOXY-5-METHYLPHENYL)-3-PHENYLPROPANOIC ACID;3-(2-METHOXY-5-METHYL-PHENYL)-3-PHENYL-PROPIONIC ACID;3-(2-Methoxyl-5-Methylphenyl)-3-PhenylpropionicAcid(ForTolterodine-L-Tartrate);2-Methoxy-5-Methyl-beta-Phenylbenzene Propanoic Acid;3-(2-Methoxy-5-methylphenyl)-3-phenylpropanoic acid cas:(intermediate of Tolterodine);3-(2-Methoxyl-5-methylphenyl)-3-phenylpropionic acid;3-(2-Methoxy-5-methylphenyl)-3-phenylpropanoic acid ,≥99%;2-Methoxy-5-Methyl-β-phenyl-hydrocinnaMic Acid
• CAS NO: 109089-77-2
• Molecular Formula: C₁₇H₁₈O₃
• Molecular Weight: 270.32
• EINECS: 1806241-263-5
• Product Categories: TOLTERODINE TARTRATE;(intermediate of Tolterodine);Aromatics Compounds;Aromatics
• Mol File: 109089-77-2.mol
• Article Data: 4

Chemical Properties

• Melting Point: 130-132°C
• Boiling Point: 419.1 °C at 760 mmHg
• Flash Point: 151.4 °C
• Appearance: white crystalline solid
• Density: 1.138 g/cm³
• Vapor Pressure: 8.98E-08mmHg at 25°C
• Refractive Index: 1.569
• Storage Temp.: 2-8°C
• Solubility: DMF, DMSO, Methanol
• CAS DataBase Reference: 3-(2-Methoxy-5-methylphenyl)-3-phenylpropanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-Methoxy-5-methylphenyl)-3-phenylpropanoic acid(109089-77-2)
• EPA Substance Registry System: 3-(2-Methoxy-5-methylphenyl)-3-phenylpropanoic acid(109089-77-2)

Safety Data

• Hazardous Substances Data: 109089-77-2(Hazardous Substances Data)

Usage

Chemical Properties

White Crystalline Solid

Uses

3-(2-Methoxy-5-methylphenyl)-3-phenyl-propanoic Acid (cas# 109089-77-2) is a compound useful in organic synthesis.

InChI:InChI=1/C17H18O3/c1-12-8-9-16(20-2)15(10-12)14(11-17(18)19)13-6-4-3-5-7-13/h3-10,14H,11H2,1-2H3,(H,18,19)

Upstream product

• 100-52-7 benzaldehyde 
• 99429-99-9 4-methylphenyl (2E)-3-phenylprop-2-enoate 
• 89530-34-7 1-phenyl-3-trimethylsilylprop-2-yn-1-ol 
• 104-93-8 p-methylanizole 
• 140-10-3 (E)-3-phenylacrylic acid 
• 685881-14-5 [3-(2-methoxy-5-methyl-phenyl)-3-phenyl-prop-1-ynyl]-trimethyl-silane 
• 40546-94-9 6-methyl-4-phenyl-3,4-dihydrocoumarin 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 124937-96-8 3-(2-methoxy-5-methyl-phenyl)-3-phenyl-propionyl chloride 
• 124935-88-2 N,N-diisopropyl-3-(2-methoxy-5-methylphenyl)-3-phenylpropan-1-amine 
• 124937-73-1 3-(2-methoxy-5-methylphenyl)-3-phenylpropan-1-ol 

Relevant articles and documents

A PROCESS FOR THE PREPARATION OF TOLTERODINE TARTRATE

The present invention relates to provide an improved process for the preparation of tolterodine or salt thereof, comprises a step of reducing 3-(2-methoxy-5-methylphenyl) -3-phenyl propionic acid of formula (III) in the presence of a reducing agent, an acidic reagent and a solvent to obtain 3-(2-methoxy-5-methylphenyl) -3-phenyl propanol of formula (IV).

p-Toluenesulfonic acid mediated hydroarylation of cinnamic acids with anisoles and phenols under metal and solvent-free conditions

Hydroarylation of cinnamic acids with anisoles and phenols mediated by p-toluenesulfonic acid (p-TSA) under metal and solvent-free conditions gave 3-(4-methoxyphenyl)-3-phenylpropanoic acids and dihydrocoumarins, respectively, in high yields and excellent selectivity.